(4E)-1-(2-HYDROXYETHYL)-4-DODECENE-6,8,10-TRIYN-1-YL beta-D-GLUCOPYRANOSIDE | 143305-04-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4E)-1-(2-HYDROXYETHYL)-4-DODECENE-6,8,10-TRIYN-1-YL beta-D-GLUCOPYRANOSIDE
• 英文别名: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(E)-1-hydroxytetradec-6-en-8,10,12-triyn-3-yl]oxyoxane-3,4,5-triol
• CAS: 143305-04-8
• 化学式: C₂₀H₂₆O₇
• 分子量: 378.4
• InChiKey: BBDICNGPTGOCAK-CKPIDSMRSA-N

物化性质

• 沸点：
  652.7±65.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Polyacetylenic compounds
  申请人：Academia Sinica

  公开号：EP2384758B1

  公开（公告）日：2013-11-13
• USE OF POLYACETYLENIC GLYCOSIDES FOR SUPPRESSION OF GRANULOCYTIC MYELOID-DERIVED SUPPRESSOR CELL ACTIVITIES AND TUMOR METASTASIS
  申请人：Academia Sinica

  公开号：US20170360863A1

  公开（公告）日：2017-12-21

  A pharmacological composition for use in inhibiting differentiation, functional activities, and population of granulo-cytic myeloid-derived suppressor cells (gMDSCs) and/or suppressing, tumor metastasis in a subject in need thereof is disclosed. The composition comprises a therapeutically effective amount of Bidens pilosa extract, or more than one polyacetylenic compounds purified or isolated from the B. pilosa extract, and a pharmaceutically acceptable carrier.