tert-butyl N-[(3-cyano-6-methoxy-4-phenylisoquinolin-1-yl)carbonyl]glycinate | 849547-83-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[(3-cyano-6-methoxy-4-phenylisoquinolin-1-yl)carbonyl]glycinate
• 英文别名: Tert-butyl 2-[(3-cyano-6-methoxy-4-phenylisoquinoline-1-carbonyl)amino]acetate
• CAS: 849547-83-7
• 化学式: C₂₄H₂₃N₃O₄
• 分子量: 417.464
• InChiKey: UXJIYYIOPBSOCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Isoquinoline potassium channel inhibitors
  申请人：Trotter Wesley B.

  公开号：US20060276450A1

  公开（公告）日：2006-12-07

  The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

  本发明涉及具有结构式（I）的化合物，可用作钾通道抑制剂治疗心律失常等。
• Solid polymer electrolyte having high-durability
  申请人：Kabushiki Kaisha Toyota Chuo Kenkyusho

  公开号：EP1110992A1

  公开（公告）日：2001-06-27

  In solid polymer electrolyte having high-durability, comprising a polymer electrolyte material having a hydrocarbon part, a chelate group and an electrolyte group are introduced into the polymer electrolyte material. The chelate group contains a phosphonic acid group, nitrogen, both of nitrogen and a phosphonic acid group (one or more selected from the group consisting of alkylamino monophosphonic acid groups, alkylamino diphosphonic acid groups, dialkylamino monophosphonic acid groups, alkylalkylene diamine triphosphonic acid groups, and alkylimino phosphonic acid groups) or, both of nitrogen and a carboxylic acid group (one or more selected from the group consisting of alkylamino monocarboxylic acid groups, alkylamino dicarboxylic acid groups, dialkylamino monocarboxylic acid groups, alkylalkylene diamine tricarboxylic acid groups, and alkylimino carboxylic acid groups).

  在具有高耐久性的固体聚合物电解质中，聚合物电解质材料由具有碳氢化合物部分的聚合物电解质材料组成，在聚合物电解质材料中引入了螯合基团和电解质基团。螯合基团包含膦酸基团、氮、氮和膦酸基团（选自烷基氨基单膦酸基团、烷基氨基二膦酸基团、二烷基氨基单膦酸基团、烷基烯二胺三膦酸基团组成的组中的一个或多个）、和烷基亚氨基膦酸基）或氮和羧酸基（选自烷基氨基一羧酸基、烷基氨基二羧酸基、二烷基氨基一羧酸基、烷基烯二胺三羧酸基和烷基亚氨基羧酸基组成的组中的一个或多个）。
• Drying substances, preparation and use thereof
  申请人：Oridion Medical 1987 Ltd.

  公开号：EP2226192A1

  公开（公告）日：2010-09-08

  There is provided herein a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both), the polymer substance includes: a porous support member having a plurality of pores, wherein at least a portion of the pores are filled with a cross-linked co-polymer comprising (i) a cationic monomer and an anionic monomer, (ii) a zwitterionic monomer, or a combination thereof. The substance may include a membrane or a tube. There is further provided herein a process for the preparation of a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both), the process includes impregnating into at least a portion of the pores of a porous support member a solution which comprises: (i) a cationic monomer and an anionic monomer, (ii) a zwitterionic monomer, or a combination of (i) and (ii), graft co-polymerizing the anionic monomer and the cationic monomer and/or the zwitterionic monomer within at least a portion of the pores to form a co-polymer, and cross-linking the co-polymer, such that the pores of the support member are at least partially grafted with a cross-linked co-polymer bound to the support member.

  本文提供了一种适用于蒸发流体（如水、水蒸气或两者）的干燥聚合物物质，该聚合物物质包括：具有多个孔隙的多孔支撑件，其中至少一部分孔隙填充有交联共聚物，该共聚物包括(i) 阳离子单体和阴离子单体，(ii) 齐聚物单体，或它们的组合。该物质可包括膜或管。本文还提供了一种用于制备干燥聚合物物质的工艺，该物质适于蒸发流体（如水、水蒸气或两者），该工艺包括将一种溶液浸渍到多孔支撑件的至少部分孔隙中，该溶液包括：(i)阳离子单体和阴离子单体，(ii)齐聚物单体，或(i)和(ii)的组合，在至少部分孔隙内接枝共聚阴离子单体和阳离子单体和/或齐聚物单体以形成共聚物，并交联共聚物，使支撑件的孔隙至少部分接枝与支撑件结合的交联共聚物。
• Drying tube, preparation and use thereof
  申请人：Oridion Medical 1987 Ltd.

  公开号：EP2226116B1

  公开（公告）日：2016-04-20
• DRYING SUBSTANCES, PREPARATION AND USE THEREOF
  申请人：ORIDION MEDICAL (1987) LTD.

  公开号：US20130116589A1

  公开（公告）日：2013-05-09

  There is provided herein a dryer polymer substance including a hetero-phase polymer composition including two or more polymers wherein at least one of the two or more polymers include sulfonic groups, wherein the substance is adapted to pervaporate a fluid. The fluid may include water, water vapor or both. There is also provided herein a process for the preparation of a dryer polymer substance adapted to pervaporate a fluid (such as water, water vapor or both) the process includes mixing two or more polymers, wherein at least one of the two or more polymers may include groups which are adapted to be sulfonated, to produce a hetero-phase polymer composition and processing the polymer blend into a desired form.