Boc-D-Phe-ψL[(E)-C(CH3)=CH]-Ala-Val-AMT | 1205539-92-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-D-Phe-ψL[(E)-C(CH3)=CH]-Ala-Val-AMT
• 英文别名: tert-butyl N-[(E,2R,5R)-3,5-dimethyl-6-[[(2S)-3-methyl-1-[(6-methyl-5,6-dihydro-4H-1,3-thiazin-2-yl)amino]-1-oxobutan-2-yl]amino]-6-oxo-1-phenylhex-3-en-2-yl]carbamate
• CAS: 1205539-92-9
• 化学式: C₂₉H₄₄N₄O₄S
• 分子量: 544.759
• InChiKey: RDESZSQEMZRJMF-JNIJOUDTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  38
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  Boc-D-Phe-ψL[(E)-C(CH3)=CH]-Ala-Val-OMe 、 AMT盐酸盐 在 4-二甲氨基吡啶 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 氯仿 为溶剂， 反应 36.0h， 以96%的产率得到Boc-D-Phe-ψL[(E)-C(CH3)=CH]-Ala-Val-AMT
  参考文献：
  名称：

  TARGETED NITROXIDE AGENTS

  摘要：

  本文提供了一种对自由基清除有用的组合物和相关方法，具有特定选择性作用于线粒体。这些化合物包括一个连接到线粒体靶向基团的亚硝基含有基团。这些化合物可以交联成二聚体而不丧失活性。本文还提供了一种用于预防、缓解和治疗辐射引起的损伤的方法。该方法包括向患者输送一种如本文所述的化合物，以有效地预防、缓解或治疗辐射引起的损伤。

  公开号：

  US20100035869A1

文献信息

• USE OF TARGETED NITROXIDE AGENTS IN PREVENTING, MITIGATING AND TREATING RADIATION INJURY
  申请人：Wipf Peter

  公开号：US20110172214A1

  公开（公告）日：2011-07-14

  Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.

  本文提供了一种有用于自由基清除的组合物和相关方法，特别是对线粒体的选择性。该化合物包括连接到线粒体靶向基团的亚硝基含有基团。该化合物可以交联成二聚体而不失去活性。本文还提供了一种方法，用于预防、缓解和治疗放射性损伤。该方法包括将上述所述的化合物以有效的剂量和用药方案输送给患者，以预防、缓解或治疗放射性损伤。
• Compounds for the treatment of pathologies associated with aging and degenerative disorders
  申请人：Niedernhofer Laura J.

  公开号：US20120004263A1

  公开（公告）日：2012-01-05

  The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. “Inhibiting a sign of aging or degenerative disorder” means reducing the risk of occurrence, delaying the onset, slowing the progression, and/or reducing the severity and/or manifestation, of a sign of aging or degenerative disorder, and includes, but is not limited to, preventing the occurrence, development or progression of a sign of aging or degenerative disorder.
• Selective Targeting Agents for Mitochondria
  申请人：Wipf Peter

  公开号：US20140107317A1

  公开（公告）日：2014-04-17

  The present invention provides a composition and related methods for delivering cargo to a mitochondria which includes (a) a membrane active peptidyl fragment having a high affinity with the mitochondria and (b) cargo. The cargo may be selected from a wide variety of desired cargoes which are to be delivered to the mitochondria for a specific purpose. Compositions and methods are disclosed for treating an illness that is caused or associated with cellular damage or dysfunction which is caused by excessive mitochondrial production of reaction oxygen species (ROS). Compositions which act as mitochondria-selective targeting agents using the structural signaling of the β-turn recognizable by cells as mitochondria) targeting sequences are discussed. Mitochondria and cell death by way of apoptosis is inhibited as a result of the ROS-scavenging activity, thereby increasing the survival rate of the patient.
• US7718603B1
  申请人：——

  公开号：US7718603B1

  公开（公告）日：2010-05-18
• US8288551B2
  申请人：——

  公开号：US8288551B2

  公开（公告）日：2012-10-16