(5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxamide | 487041-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxamide
• 英文别名: (5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidine-5-carboxamide
• CAS: 487041-17-8
• 化学式: C₁₅H₁₅FN₂O₃S
• 分子量: 322.36
• InChiKey: JCSCLHOUNBXMEE-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxamide 在 四氧化锇 N-甲基吗啉氧化物 作用下， 以 水 、 丙酮 为溶剂， 反应 43.0h， 生成 (5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxamide S,S-dioxide
  参考文献：
  名称：

  Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound

  摘要：

  本发明涉及具有改善溶解性的新型酰胺化合物，以及改善酰胺化合物溶解性的方法。这些酰胺化合物包括噁唑烷酮化合物，通过改善其溶解性来提高这些噁唑烷酮化合物的生物利用度。

  公开号：

  US20040014967A1
• 作为产物：
  描述：

  methyl (5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxylate 在 ammonium hydroxide 作用下， 反应 0.5h， 以82%的产率得到(5R)-3-[4-(3,6-dihydro-2H-thiopyran-4-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinecarboxamide
  参考文献：
  名称：

  Antibacterial Oxazolidinones Possessing a Novel C-5 Side Chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic Acid Amide (PF-00422602), a New Lead Compound

  摘要：

  Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus possess less potential for the side effects associated with MAO inhibition. The title compound (14) showed reduced in vivo myelotoxicity compared to linezolid in a 14-day safety study in rats, potent in vivo efficacy in murine systemic infection models, and excellent pharmacokinetic properties.

  DOI：

  10.1021/jm070708p

文献信息

• N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
  申请人：——

  公开号：US20040147760A1

  公开（公告）日：2004-07-29

  The present invention provides antibacterial agents having the formulae I, II, and III described herein.

  本发明提供了具有以下式I、II和III的抗菌剂。
• [EN] N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS<br/>[FR] N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES ET LEURS DERIVES ET UTILISATION DE CES COMPOSES COMME ANTIBACTERIENS
  申请人：UPJOHN CO

  公开号：WO2003072553A1

  公开（公告）日：2003-09-04

  Compounds of formula B-C-A-CO-NH-R1, wherein A is structure i, ii or iii: formulae (I), (II), (III). C is optionally substituted aryl or heteroaryl, and B is a specified cyclic moiety, or C and B together are a heterobicyclic moiety, are useful as antibacterial agents.

  公式为B-C-A-CO-NH-R1的化合物，其中A是结构i、ii或iii：公式(I)、(II)、(III)。C是可选择取代的芳基或杂环芳基，而B是特定的环状基团，或者C和B一起是一个杂双环基团，可用作抗菌剂。
• N-Aryl-2-oxazolidinone-5-carboxamides and their derivatives
  申请人：——

  公开号：US20040044052A1

  公开（公告）日：2004-03-04

  The present invention provides antibacterial agents having the formulae I, II, and III described herein.

  本发明提供了具有以下公式I、II和III的抗菌剂。
• AMIDE DERIVATIVES HAVING IMPROVED SOLUBILITY
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1451164A2

  公开（公告）日：2004-09-01
• N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS
  申请人：Pharmacia & Upjohn Company LLC

  公开号：EP1478629B1

  公开（公告）日：2006-10-11