10-Hydroxy-9-sulfostearic acid | 69975-97-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10-Hydroxy-9-sulfostearic acid
• 英文别名: 10-hydroxy-9-sulfooctadecanoic acid
• CAS: 69975-97-9
• 化学式: C₁₈H₃₆O₆S
• 分子量: 380.5
• InChiKey: RQDFBKXDHPITFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICROBIAL AGENTS
  申请人：Li Junzhong

  公开号：US20100021557A1

  公开（公告）日：2010-01-28

  The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

  本发明涉及新型磺酰过氧羧酸化合物及其制备和使用方法。本发明的磺酰过氧羧酸化合物具有储存稳定性、水溶性和低至无气味。此外，本发明的化合物可由非石油基可再生材料制成。本发明的化合物可用作抗菌剂和漂白剂。本发明的化合物也适用于用作偶联剂。
• DETERGENTS CAPABLE OF CLEANING, BLEACHING, SANITIZING AND/OR DISINFECTING TEXTILES INCLUDING SULFOPEROXYCARBOXYLIC ACIDS
  申请人：Gohl David W.

  公开号：US20120225943A1

  公开（公告）日：2012-09-06

  The present invention relates to novel combined laundry detergent, bleach, and antimicrobial composition incorporating novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds used in compositions of the invention are storage stable, water soluble and have low to no odor. Compositions of the invention may be in the form of a liquid, a solid, or a gel. The sulfoperoxycarboxylic compounds useful in preparing compositions of the present invention can be formed from non-petroleum based renewable materials.

  本发明涉及一种新型的组合洗涤剂、漂白剂和抗菌剂组合物，其中包括新型的磺基过氧羧酸化合物，并提供制备和使用它们的方法。本发明中使用的磺基过氧羧酸化合物具有储存稳定性、水溶性和低至无气味。本发明中的组合物可以是液体、固体或凝胶。本发明中用于制备组合物的磺基过氧羧酸化合物可以由非石油基可再生材料形成。
• SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICROBIAL AGENTS (PSOA)
  申请人：Li Junzhong

  公开号：US20130041030A1

  公开（公告）日：2013-02-14

  The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

  本发明涉及新型的磺酰过氧羧酸化合物以及制备和使用它们的方法。本发明的磺酰过氧羧酸化合物具有储存稳定性，水溶性和低至无气味。此外，本发明的化合物可以由非石油基可再生材料制成。本发明的化合物可用作抗微生物剂和漂白剂。本发明的化合物也适用于用作偶联剂。
• ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS
  申请人：The Hong Kong Polytechnic University

  公开号：US20150011513A1

  公开（公告）日：2015-01-08

  A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (Az 1-15) and alkynes (Ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (MDR) in P-gp-overexpressed cell line (LCC6MDR), MRP1-overexpressed cell line (2008/MRP1) and BCRP-overexpressed cell line (HEK293/R2 and MCF7-MX100). Generally, they displayed very promising MDR reversal activity against P-gp-, MRP1- and BCRP-mediated drug resistance. Moreover, they showed different levels of selectivity for various transporters. Overall, they can be divided into mono-selective, dual-selective and multi-selective modulators for the P-gp, MRP1 and BCRP transporters. The EC50 values for reversing paclitaxel resistance (141-340 nM) of LCC6MDR cells, DOX (78-590 nM) and vincristine (82-550 nM) resistance of 2008/MRP1 cells and topotecan resistance (0.9-135 nM) of HEK293/R2 and MCF7-MX100 cells were at nanomolar range. Importantly, a number of compounds displayed EC50 at or below 10 nM in BCRP-overexpressed cell lines, indicating that these bivalent triazoles more selectively inhibit BCRP transporter than the P-gp and MRP1 transporters. Most of the dimers are notably safe MDR chemosensitizers as indicated by their high therapeutic index values.

  通过一系列含有三唑桥联类黄酮二聚物的合成，使用环加成反应，利用一系列含有黄酮基团的叠氮化物（Az1-15）和炔烃（Ac1-17）构建了一个高效的化合物库。这些三唑桥联的类黄酮二聚体及其前体炔基和叠氮基类黄酮被筛选，以评估它们对过表达P-gp的细胞系（LCC6MDR）、MRP1过表达的细胞系（2008/MRP1）和BCRP过表达的细胞系（HEK293/R2和MCF7-MX100）调节多药耐药性（MDR）的能力。总体而言，它们展现了极具前景的P-gp、MRP1和BCRP介导的药物耐药性的MDR逆转活性。此外，它们显示出对各种转运体的不同程度的选择性。总体而言，它们可以分为单选择性、双选择性和多选择性的P-gp、MRP1和BCRP转运体调节剂。对于LCC6MDR细胞的紫杉醇耐药性（141-340 nM）、2008/MRP1细胞的DOX（78-590 nM）和长春新碱（82-550 nM）耐药性以及HEK293/R2和MCF7-MX100细胞的拓扑替康耐药性（0.9-135 nM），它们的EC50值处于纳摩尔范围。重要的是，许多化合物在BCRP过表达的细胞系中显示出EC50值在或低于10 nM，表明这些双价三唑更有选择性地抑制BCRP转运体而不是P-gp和MRP1转运体。大多数二聚体的治疗指数值非常高，表明它们是非常安全的MDR化疗敏感剂。
• SULFOPEROXYCARBOXYLIC ACIDS, THEIR PREPARATION AND METHODS OF USE AS BLEACHING AND ANTIMICORBIAL
  申请人：Ecolab USA Inc.

  公开号：US20160168087A1

  公开（公告）日：2016-06-16

  The present invention relates to novel sulfoperoxycarboxylic acid compounds, and methods for making and using them. The sulfoperoxycarboxylic compounds of the invention are storage stable, water soluble and have low to no odor. Further, the compounds of the present invention can be formed from non-petroleum based renewable materials. The compounds of the present invention can be used as antimicrobials, and bleaching agents. The compounds of the present invention are also suitable for use as coupling agents.

  本发明涉及新型的磺酸过氧羧酸化合物及其制备和使用方法。本发明的磺酸过氧羧酸化合物具有储存稳定性、水溶性和低至无异味。此外，本发明的化合物可以由非石油基可再生材料制备而成。本发明的化合物可用作抗菌剂和漂白剂。本发明的化合物还适用于用作偶联剂。