O-3-sulfopropyl-L-tyrosine N-methylamide | 391222-88-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: O-3-sulfopropyl-L-tyrosine N-methylamide
• 英文别名: 3-[4-[(2S)-2-amino-3-(methylamino)-3-oxopropyl]phenoxy]propane-1-sulfonic acid
• CAS: 391222-88-1
• 化学式: C₁₃H₂₀N₂O₅S
• 分子量: 316.378
• InChiKey: OMRXIHFHDICOGV-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Sulfonic acid derivatives of hydroxamic acids and their use as medicinal products
  申请人：——

  公开号：US20030176486A1

  公开（公告）日：2003-09-18

  The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

  本发明涉及羟羰酸的新型磺酸衍生物或其药理学上可接受的盐。更具体地，本发明涉及一种羟羰酸的磺酸衍生物或其药理学上可接受的盐，其用作脂多糖（LPS）的抑制剂。此外，本发明涉及一种新型中间化合物，用于合成这种羟羰酸的磺酸衍生物。
• SULFONIC ACID DERIVATIVES OF HYDROXAMIC ACIDS AND THEIR USE AS MEDICINAL PRODUCTS
  申请人：Welfide Corporation

  公开号：EP1306367A1

  公开（公告）日：2003-05-02

  The present invention relates to a novel sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof. More particularly, the present invention relates to a sulfonic acid derivative of hydroxamic acid or a pharmacologically acceptable salt thereof, which is useful as an inhibitor of lipopolysaccharides (LPS). In addition, the present invention relates to a novel intermediate compound useful for the synthesis of this sulfonic acid derivative of hydroxamic acid.

  本发明涉及一种新型羟肟酸磺酸衍生物或其药理学上可接受的盐。更具体地说，本发明涉及一种羟肟酸的磺酸衍生物或其药理学上可接受的盐，可用作脂多糖（LPS）的抑制剂。此外，本发明还涉及一种可用于合成羟肟酸磺酸衍生物的新型中间体化合物。
• US6989401B2
  申请人：——

  公开号：US6989401B2

  公开（公告）日：2006-01-24