| 1331740-11-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 1331740-11-4
• 化学式: C₁₆H₁₀ClNO₄
• 分子量: 315.713
• InChiKey: KTFWLNGFTPWBPR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  benzyl ((3R,4S,5R)-5,6-dihydroxy-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl)carbamate 、 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 生成 N-(7-(((2S,3R,4S,5R)-4-amino-3-hydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-8-chloro-2-oxo-2H-chromen-3-yl)benzamide
  参考文献：
  名称：

  Simplified aminocoumarin analogues as anticancer agents: Amino isosteric replacement in the noviose moiety resulted in substantial enhancement of antiproliferative activity

  摘要：

  Simplified aminocoumarin analogues, either noviosylated or simple basic heterocycle attached 3-amidocoumarin compounds, are known to be promising anticancer agents targeting the C-terminal ATP-binding site of Hsp90. In this study, 3'-amino isosteric replacement in the noviose moiety of two known noviose containing Hsp90 C-terminal inhibitors was synthetically realized for the first time. In vitro evaluation of these compounds suggested that the introduction of a basic amino group into the noviose subunit resulted in significant improvement of their cytotoxicities. (C) 2013 Yun-Feng Li and Nan Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2013.04.046