3-苄基-6-异丁基-2,5-哌嗪二酮 | 3354-31-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-苄基-6-异丁基-2,5-哌嗪二酮
• 英文名称: 3-(2-methylpropyl)-6-benzyl-2,5-diketopiperazine
• 英文别名: 3-Benzyl-6-isobutylpiperazine-2,5-dione；c-L-Leu-D-Phe；cyclo(Leu-Phe)；Cyclo-leu-phe；3-benzyl-6-isobutyl-piperazine-2,5-dione；3-Benzyl-6-isobutyl-piperazin-2,5-dion；Cyclo(Phe-Leu)；3-benzyl-6-(2-methylpropyl)piperazine-2,5-dione
• CAS: 3354-31-2
• 化学式: C₁₅H₂₀N₂O₂
• 分子量: 260.336
• InChiKey: QPDMOMIYLJMOQJ-UHFFFAOYSA-N

物化性质

• 沸点：
  521.0±43.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  D-苯丙氨酸甲酯盐酸盐 在 甲酸 、 N,N'-二环己基碳二亚胺 作用下， 以 甲苯 、 仲丁醇 为溶剂， 反应 2.0h， 生成 3-苄基-6-异丁基-2,5-哌嗪二酮
  参考文献：
  名称：

  Conformational effects in reversed-phase liquid chromatographic separation of diastereomers of cyclic dipeptides

  摘要：

  The capacity factors, k', of 11 cyclic dipeptides (X-Y) including diastereomers have been determined on an RP-HPLC column in 30% and 50% methanol and 10%, 30%, and 50% acetonitrile solutions. These factors are roughly correlated with hydrophobic parameters, such as octanol-water partition coefficients estimated and k' values for alcohols. For a pair of diastereomers of cyclic (L-X-L-Phe) and (L-X-D-Phe) derivatives k'LL is larger than k'LD, and for cyclic (D-Ala-L-Trp) and (L-Ala-L-Trp) k'LL is smaller than k'DL, particularly in highly aqueous solutions. These elution orders can be well predicted by the holistic molecular surface area approach which takes into account the folded structures of cyclic dipeptides. The present results will be useful for prediction of the log k' values of larger peptides and the hydrophobicity and related properties of peptides.

  DOI：

  10.1021/ac00062a010

文献信息

• AGRICULTURAL CHEMICAL CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Republic of Korea (Management: Rural Development Administration)

  公开号：EP2594134A2

  公开（公告）日：2013-05-22

  Disclosed herein is an agricultural agent containing a 2,5-diketopiperazine derivative capable of controlling plant diseases and promoting plant growth or an agriculturally acceptable salt thereof as an active ingredient.

  本文公开了一种农用制剂，其活性成分含有能够控制植物病害和促进植物生长的 2,5-二酮哌嗪衍生物或其农业上可接受的盐。
• COMBUSTIBLE PRODUCT
  申请人：Industrial Chemicals Group Limited

  公开号：EP3231856A1

  公开（公告）日：2017-10-18

  A process for producing combustible product from an organic or biomass feedstock, the process comprising: mixing the feedstock with an alkaline material to give an alkaline aqueous mixture; reacting the mixture under subcritical conditions at a temperature in the range of about 280°C to about 320°C and a pressure of about 6.6 MPato about 11.6 MPa (65 bar gauge to about 115 bar gauge); and removing at least some of the water to leave a combustible product, which may be used to form an aqueous slurry, suspension or emulsion and combusted in a suitable engine.

  一种利用有机或生物质原料生产可燃产品的工艺，该工艺包括 将原料与一种碱性材料混合，得到一种碱性含水混合物； 在温度约 280°C 至约 320°C、压力约 6.6 兆帕至约 11.6 兆帕（65 巴至约 115 巴）的亚临界条件下，使混合物发生反应；以及 除去至少一部分水，留下可燃产物，该产物可用于形成水性浆液、悬浮液或乳液，并在合适的发动机中燃烧。
• Processes and host cells for genome, pathway, and biomolecular engineering
  申请人：enEvolv, Inc.

  公开号：US10370654B2

  公开（公告）日：2019-08-06

  The present disclosure provides compositions and methods for genomic engineering.

  本公开提供了基因组工程的组合物和方法。
• Solution casting method and polymer film
  申请人：Sugiura Masaru

  公开号：US20050077648A1

  公开（公告）日：2005-04-14

  A solvent in which dichloromethane is mixed with alcohol as a poor solvent is used for preparing a dope. Alcohol is supplied to the dope in a inline pipe to mix with a static mixer, such as a casting dope in which a composition of alcohol is increased. The temperature of the rotary drum is adjusted to −7° C. The casting dope is fed from a casting die to the rotary drum so as to form a casting film whose thickness is 40 μm. Since the content of alcohol is high and a storage modulus of the cooled casting film is at least 150 thousands Pa, the peeling defect does not occur, and the stretch is reduced as far as possible. A gel-like film is dried by a tenter type drying device, and stretched such that the stretch ratio is at most 110%. The produced film is thin and excellent in a surface condition and optical isotropy.

  二氯甲烷与作为劣质溶剂的酒精混合的溶剂用于制备涂料。酒精通过内联管道供应到涂料中，与静态混合器混合，如增加酒精成分的铸造涂料。将浇注料从浇注模具送入旋转滚筒，以形成厚度为 40 μm 的浇注膜。由于酒精含量高，冷却后的浇注膜的储存模量至少为 15 万帕，因此不会出现剥离缺陷，拉伸也尽可能减小。凝胶状薄膜由拉幅机干燥，拉伸率不超过 110%。生产出的薄膜很薄，表面状态和光学各向同性都很好。
• USE OF AN AGRICULTURAL AGENT CONTAINING 2,5-DIKETOPIPERAZINE DERIVATIVE AS ACTIVE INGREDIENT
  申请人：Republic of Korea (Management: Rural Development Administration)

  公开号：EP2594134B1

  公开（公告）日：2017-08-02