(-)-N-甲基-N-苄基-(R)-亮氨酸 | 89384-52-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (-)-N-甲基-N-苄基-(R)-亮氨酸
• 英文名称: (-)-N-methyl-N-benzyl-(R)-Leu
• 英文别名: (2R)-2-[benzyl(methyl)amino]-4-methylpentanoic acid
• CAS: 89384-52-1
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.326
• InChiKey: BMANSRYJGUIRIZ-CYBMUJFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-N-甲基-N-苄基-(R)-亮氨酸 在 sodium hydroxide 、 双氧水 作用下， 反应 40.0h， 生成 N-methyl-N-benzyl-(R)-Leu (-)-N-oxide 、 N-methyl-N-benzyl-(R)-Leu N-oxide
  参考文献：
  名称：

  Marks, Krystyna; Siemion, Ignacy Z.; Sucharda-Sobczyk, Anna, Polish Journal of Chemistry, 1982, vol. 56, # 1, p. 109 - 121

  摘要：

  DOI：

文献信息

• TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：EP1276491A1

  公开（公告）日：2003-01-22
• EP1276491A4
  申请人：——

  公开号：EP1276491A4

  公开（公告）日：2004-08-25
• Deoxo-proline-containing tamandarin and didemnin analogs, dehydro-proline-containing tamandarin and didemnin analogs, and methods of making and using them
  申请人：Joullie M. Madeleine

  公开号：US20070129289A1

  公开（公告）日：2007-06-07

  The present invention relates to tamandarin and didemnin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
• US7651997B2
  申请人：——

  公开号：US7651997B2

  公开（公告）日：2010-01-26
• [EN] TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM<br/>[FR] ANALOGUES DE TAMANDARINE ET DE DIDEMNINE ET METHODES DE FABRICATION ET D'UTILISATION CORRESPONDANTES
  申请人：UNIV PENNSYLVANIA

  公开号：WO2001076616A1

  公开（公告）日：2001-10-18

  The present invention relates to didemnin analogs, including tamandarin analogs and didemnin and tamandarin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.