6,8-diiodo-2-methyl-4H-benzo[d][1,3]oxazin-4-one | 17987-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6,8-diiodo-2-methyl-4H-benzo[d][1,3]oxazin-4-one
• 英文别名: 6,8-diiodo-2-methyl-benzo[d][1,3]oxazin-4-one；6,8-diiodo-2-methyl-benz[d][1,3]oxazin-4-one；6,8-Dijod-2-methyl-benz[d][1,3]oxazin-4-on；3,5-Diiodacetanthranil；6,8-diiodo-2-methyl-4H-3,1-benzoxazin-4-one；6,8-diiodo-2-methyl-3,1-benzoxazin-4-one
• CAS: 17987-78-9
• 化学式: C₉H₅I₂NO₂
• 分子量: 412.953
• InChiKey: OPMJBYPHTDLWBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,8-diiodo-2-methyl-4H-benzo[d][1,3]oxazin-4-one 在 1,4-二氧六环 、 sodium hydroxide 作用下， 生成 2-乙酰氨基-3,5-二碘苯甲酸
  参考文献：
  名称：

  X-Ray Contrast Media. I. Iodinated Acylaminobenzoic Acids¹

  摘要：

  DOI：

  10.1021/ja01137a035
• 作为产物：
  描述：

  邻氨基苯甲酸 在 盐酸 、 硫酸 、 一氯化碘 作用下， 生成 6,8-diiodo-2-methyl-4H-benzo[d][1,3]oxazin-4-one
  参考文献：
  名称：

  X-Ray Contrast Media. I. Iodinated Acylaminobenzoic Acids¹

  摘要：

  DOI：

  10.1021/ja01137a035

文献信息

• Heterocyclic Compound
  申请人：Amasaki Ichiro

  公开号：US20100004439A1

  公开（公告）日：2010-01-07

  A compound represented by the following Formula (1): wherein, Het 1 represents a bivalent five- or six-membered aromatic heterocyclic residue and may further be substituted; X a to X d each independently represent a heteroatom and may further be substituted; Y a to Y f each independently represent a heteroatom or a carbon atom and may further be substituted; the ring bound to Het 1 may have a double bond at any position

  以下是您提供的化学公式(1)的中文翻译： 其中，Het1代表一个二价的五元或六元芳香杂环基团，且可以进一步被取代；Xa至Xd每个独立地代表一个杂原子，且可以进一步被取代；Ya至Yf每个独立地代表一个杂原子或一个碳原子，且可以进一步被取代；与Het1相连的环可以在任何位置有一个双键。
• Gaux,B.; Le Henaff,P., Bulletin de la Societe Chimique de France, 1974, p. 900 - 904
  作者：Gaux,B.、Le Henaff,P.

  DOI：——

  日期：——
• Design, synthesis, and biological evaluation studies of novel quinazolinone derivatives as anticonvulsant agents
  作者：Mohamed F. Zayed、Hany E. A. Ahmed、Abdel-Sattar M. Omar、Adel S. Abdelrahim、Khaled El-Adl

  DOI：10.1007/s00044-013-0569-5

  日期：2013.12

  In view of their expected anticonvulsant activity, some novel derivatives of 6,8-diiodo-2-methyl-3-substituted-quinazolin-4(3H)-ones (4-14) were synthesized, evaluated for their anticonvulsant activity by the maximal electroshock-induced seizure and subcutaneous pentylenetetrazole tests. The neurotoxicity was assessed using rotorod test. All the tested compounds showed considerable anticonvulsant activity in at least one of the anticonvulsant tests. Compounds 5, 6, and 8 proved to be the most potent compounds of this series with relatively low neurotoxicity and low toxicity in the median lethal dose test when compared with the reference drugs. The obtained results showed that the most potent compounds could be useful as a template for future design, optimization, and investigation to produce more active analogs.
• Iodinated 2-acylamino benzoyl derivatives of amino acids
  申请人：MALLINCKRODT CHEMICAL WORKS

  公开号：US02587936A1

  公开（公告）日：1952-03-04
• Ultraviolet Absorbent and Heterocyclic Compound
  申请人：Amasaki Ichiro

  公开号：US20090239982A1

  公开（公告）日：2009-09-24

  An ultraviolet absorbent represented by the following Formula (1) or (6): wherein, Het 1 represents a monovalent five- or six-membered aromatic heterocyclic residue; X a and X b each independently represent a heteroatom; Y a to Y c each independently represent a heteroatom or a carbon atom; the ring formed from carbon atom, X a , X b , Y a to Y c may have a double bond at any position and has at least one fused ring; wherein, Het 6 represents a monovalent five- or six-membered aromatic heterocyclic residue; X 6a and X 6b each independently represent a heteroatom; Y 6a , Y 6b and Y 6c each independently represent a heteroatom or a carbon atom; L 6 represents a bi- to octa-valent connecting group; n is an integer of 2 or more, and m is an integer of 0 or more.