ethyl (2S)-1-(4-methylphenyl)sulfonyl-6-oxo-2-phenyl-2,5-dihydropyridine-4-carboxylate | 1373869-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2S)-1-(4-methylphenyl)sulfonyl-6-oxo-2-phenyl-2,5-dihydropyridine-4-carboxylate
• CAS: 1373869-63-6
• 化学式: C₂₁H₂₁NO₅S
• 分子量: 399.467
• InChiKey: AYDIMNCUFGDEFR-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  89.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对甲苯磺酰胺 在 bis-triphenylphosphine-palladium(II) chloride 、 tris-(dibenzylideneacetone)dipalladium(0) 、 copper(l) iodide 、 sodium hydride 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲苯 、 mineral oil 为溶剂， 反应 4.17h， 生成 、 ethyl (2S)-1-(4-methylphenyl)sulfonyl-6-oxo-2-phenyl-2,5-dihydropyridine-4-carboxylate
  参考文献：
  名称：

  Palladium-Catalyzed Asymmetric 6-Endo Cyclization of Dienamides with Substituent-Driven Activation

  摘要：

  Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents.

  DOI：

  10.1021/ol300737t

文献信息

• Palladium-Catalyzed Asymmetric 6-Endo Cyclization of Dienamides with Substituent-Driven Activation
  作者：Hiroshi Tsuchikawa、Yuya Maekawa、Shigeo Katsumura

  DOI：10.1021/ol300737t

  日期：2012.5.4

  Chiral 2-piperidinone compounds with various C-6 substituents were successfully synthesized via a Pd-catalyzed asymmetric 6-endo cyclization of dienamides, which were evidently activated by both N-p-toluenesulfonyl and C-3 ester substituents.