2,3-dihydro-1H-indene-2-thiol | 83774-87-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 2,3-dihydro-1H-indene-2-thiol
• CAS: 83774-87-2
• 化学式: C₉H₁₀S
• mdl: MFCD12067424
• 分子量: 150.24
• InChiKey: JQITYXAHMGVHIR-UHFFFAOYSA-N

物化性质

• 沸点：
  254-255 °C(Press: 754 Torr)
• 密度：
  1.11±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Penem derivatives and antimicrobial agents containing the same
  申请人：SUNTORY LIMITED

  公开号：EP0774465A1

  公开（公告）日：1997-05-21

  Penem derivatives represented by the following Formula (I): wherein Z represents a hydroxyl group or a fluorine atom, R1 represents a substituted or unsubstituted alkyl, alkenyl, aralkyl group, aryl group, heterocyclic, or acyl group, or a hydrogen atom, and R2 represents a hydrogen atom or a carboxyl-protecting group; and pharmacologically acceptable salts thereof are antibacterial agents effective against, inter alia, methicillin-resistant Staphylococcus aureus. The derivatives and salts are novel except when R1 is ethyl and Z is hydroxyl. The analogous compounds in which R2 is a carboxyl-protecting group and any hydroxyl group represented by Z is protected are novel process intermediates.

  Penem衍生物由以下公式（I）表示：其中Z代表一个羟基团或氟原子，R1代表一个取代或未取代的烷基，烯基，芳基甲基，芳基，杂环基或酰基，或氢原子，R2代表一个氢原子或羧基保护基；及其药理学上可接受的盐是有效的抗菌剂，可用于治疗耐甲氧西林金黄色葡萄球菌等感染。这些衍生物和盐是新颖的，除非R1是乙基且Z是羟基。其中R2是羧基保护基且Z代表的任何羟基被保护的类似化合物是新颖的工艺中间体。
• Penem derivatives and antimicrobial agent containing the same
  申请人：Ishiguro Masaji

  公开号：US20050004092A1

  公开（公告）日：2005-01-06

  A penem derivative represented by the following formula (I): wherein R 1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R 2 represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be-effective.

  以下是公式（I）所代表的一种青霉烷衍生物： 其中，R1代表取代或未取代的烷基、取代或未取代的烯基、取代或未取代的芳基烷基、取代或未取代的芳基、取代或未取代的烷基硫基、取代或未取代的烯基硫基、取代或未取代的芳基烷基硫基、取代或未取代的芳基硫基、取代或未取代的杂环基、取代或未取代的杂环硫基、取代或未取代的酰基硫基、巯基或氢原子，R2代表氢原子或羧酸保护基；或其药学上可接受的盐。该化合物（I）表现出强大的抗菌活性，特别是对MRSA表现出强大的活性。因此，它不仅有用作一般抗菌剂，还有用作抗MRSA的抗菌剂，对于这种细菌，一般的抗菌剂被认为无效。
• SODIUM CHANNEL INHIBITORS
  申请人：Beaudoin Serge

  公开号：US20100267782A1

  公开（公告）日：2010-10-21

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了一种在通过抑制电压门控钠通道的钠离子通量治疗疾病方面有用的化合物、组合物和方法。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻断与所述疾病的发生或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道的离子通量治疗神经病理性或炎症性疼痛。
• Sodium Channel Inhibitors
  申请人：Icagen Inc.

  公开号：US20140357685A1

  公开（公告）日：2014-12-04

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了在治疗疾病中通过抑制电压门控钠通道中的钠离子通量而有用的化合物、组合物和方法。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻断与指示疾病发生或复发相关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子通量来治疗神经病理性或炎症性疼痛。
• Carbapenem derivatives and antimicrobial agents comprising the same
  申请人：SUNTORY LIMITED

  公开号：EP0826687A1

  公开（公告）日：1998-03-04

  Carbapenem derivatives represented by the following Formula I, wherein R1 represents hydrogen, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic, R2 represents hydrogen or a protective group for carboxyl, and R3 represents methyl or ethyl; and pharmaceutically acceptable salts thereof are antimicrobial agents effective against, inter alia, methicillin-resistant Staphylococcus aureus. The analogous compounds in which (a) R1 is a substituted or unsubstituted alkyl, alkenyl, aralkyl or acyl group, R2 is a carboxyl-protecting group or or (b) R1 is a substituted or unsubstituted alkyl, alkenyl, aralkyl, aryl, heterocyclic or acyl group, R2 is a carboxyl-protecting group and the hydroxyl group is protected are novel process intermediates.

  由下式 I 代表的碳青霉烯类衍生物、 其中 R1 代表氢、取代或未取代的芳基或取代或未取代的杂环基，R2 代表氢或羧基保护基团，R3 代表甲基或乙基；及其药学上可接受的盐类是对耐甲氧西林金黄色葡萄球菌等有效的抗菌剂。(a) R1 是取代或未取代的烷基、烯基、芳烷基或酰基，R2 是羧基保护基团，或 (b) R1 是取代或未取代的烷基、烯基、芳烷基、芳基、杂环基或酰基，R2 是羧基保护基团且羟基受到保护的类似化合物是新型工艺中间体。