7-Phenyl-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidin | 71435-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-Phenyl-4-oxo-3H,5H-pyrrolo<3,2-d>pyrimidin
• 英文别名: 7-phenyl-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one；7-phenyl-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one；7-phenyl-3,5-dihydropyrrolo[3,2-d]pyrimidin-4-one
• CAS: 71435-39-7
• 化学式: C₁₂H₉N₃O
• mdl: MFCD17018626
• 分子量: 211.223
• InChiKey: FRFOBNOUFSXEHO-UHFFFAOYSA-N

物化性质

• 沸点：
  561.0±43.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.2
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• ISOTHIAZOLOPYRIMIDINONES, PYRAZOLOPYRIMIDINONES, AND PYRROLOPYRIMIDINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
  申请人：Forma Therapeutics, Inc.

  公开号：US20160229872A1

  公开（公告）日：2016-08-11

  The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 5′ , X 1 , X 2 , X 3 , n, and m are described herein.

  该披露涉及对USP7抑制剂的抑制剂，用于治疗癌症、神经退行性疾病、免疫性疾病、炎症性疾病、心血管疾病、缺血性疾病、病毒感染和疾病以及细菌感染和疾病，其化学式为：其中R1、R2、R3、R4、R5、R5'、X1、X2、X3、n和m如所述。
• (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10654849B2

  公开（公告）日：2020-05-19

  Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.

  式(I)化合物： 其中 R1、R2、J、K、L、n 和 W 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂和/或抗增生剂的病症。
• Substituted piperidines for the treatment of cancer
  申请人：LES LABORATOIRES SERVIER

  公开号：US11046681B2

  公开（公告）日：2021-06-29

  Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.

  式(I)化合物： 其中 R1、R2、R3、n 和 W 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂和/或抗增生剂的疾病。
• NEW (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3468971B1

  公开（公告）日：2020-02-19
• NEW PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3468974B1

  公开（公告）日：2020-02-12