6-(4-aminobutylamino)-6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose | 1227616-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: 6-(4-aminobutylamino)-6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose
• CAS: 1227616-49-0
• 化学式: C₁₆H₃₀N₂O₅
• 分子量: 330.425
• InChiKey: CDXZPVGYGHVWOG-MBJXGIAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.71
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  84.2
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  6-(4-aminobutylamino)-6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-galactopyranose 、 1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 72.0h， 以56%的产率得到1-cyclopropyl-7-[N-(6-deoxy-1,2:3,4-di-O-isopropylidene-α-D-glucopyranos-6-yl-aminobutylamino)]-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  Synthesis and antitubercular evaluation of new fluoroquinolone derivatives coupled with carbohydrates

  摘要：

  We describe in this work the synthesis of nine new fluoroquinolone derivatives based on modifications at the C-7 position of the known fluoroquinolones cipro-, gati-, and moxifloxacin, as well as their antitubercular evaluation. The synthesis of these new analogues was improved using microwave irradiation, providing several advantages such as better yields and shorter reaction times, in comparison with classical reaction conditions. Derivatives 4, 5, and 7 exhibited promising antitubercular activities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.01.016