3.5-Dimethyl-3'-isopropyl-L-thyronin | 26384-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3.5-Dimethyl-3'-isopropyl-L-thyronin
• 英文别名: DIMIT；2-Amino-3-[4-(4-hydroxy-3-propan-2-ylphenoxy)-3,5-dimethylphenyl]propanoic acid
• CAS: 26384-20-3
• 化学式: C₂₀H₂₅NO₄
• 分子量: 343.423
• InChiKey: QHHWMOKQVCJRPS-UHFFFAOYSA-N

物化性质

• 沸点：
  493.1±45.0 °C(Predicted)
• 密度：
  1.187±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] DERIVATIVES OF SOBETIROME<br/>[FR] DÉRIVÉS DE SOBÉTIROME
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2017201320A1

  公开（公告）日：2017-11-23

  Disclosed are halo substituted derivative compounds of sobetirome with improved pharmacological characteristics relative to sobetirome, pharmaceutical compositions that include those compounds and methods of treating diseases such as neurodegenerative disorders using those pharmaceutical compositions.

  揭示了具有相对于sobetirome改进的药理特性的halo取代衍生物化合物，包括这些化合物的药物组合物以及使用这些药物组合物治疗神经退行性疾病等疾病的方法。
• Nuclear receptor ligands and ligand binding domains
  申请人：Baxter D. John

  公开号：US20070027215A1

  公开（公告）日：2007-02-01

  The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as “TR”). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.

  本发明提供了新的方法，特别是计算方法和组合物，用于基于核受体的三维结构，特别是甲状腺受体（以下简称“TR”）生成核受体合成配体。还提供了晶体、核受体合成配体和相关方法。
• Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
  申请人：UNIVERSITY OF MIAMI

  公开号：EP0048159A2

  公开（公告）日：1982-03-24

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula Wherein X = X, O or NR9, R4 and R5 form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 X = X、O 或 NR9，R4 和 R5 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自已公开的各种基团。
• Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides
  申请人：Ryan, James Walter

  公开号：EP0073143A2

  公开（公告）日：1983-03-02

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula wherein R, and/or R3 form complex amides and imides thereof, X = S, O or NR3, R4 and Rs form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 R 和/或 R3 形成其复合酰胺和亚胺，X = S、O 或 NR3，R4 和 Rs 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自各种已公开的基团。
• PROCESS FOR THE PREPARATION OF DERIVATIVES OF SOBETIROME
  申请人：Oregon Health & Science University

  公开号：EP3936497A1

  公开（公告）日：2022-01-12

  The present invention concerns a process for the preparation of compounds of Formula (I) where each R is chloro or each R is bromo.

  本发明涉及一种制备式（I）化合物的工艺，其中每个 R 均为氯或每个 R 均为溴。