3-iodopropanesulphonamide | 88497-02-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 3-iodopropanesulphonamide
• 英文别名: 3-Iod-propan-sulfonsaeure-(1)-amid；3-aminosulfonyl-1-iodopropane；3-iodopropylsulfonamide；3-iodopropane-1-sulfonamide；3-Iodopropanesulfonamide
• CAS: 88497-02-3
• 化学式: C₃H₈INO₂S
• 分子量: 249.073
• InChiKey: MUYMCKSQCZEKSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-iodopropanesulphonamide 生成 3-(Imidazo[1,2-a]pyridin-5-ylsulfanyl)-propane-1-sulfonic acid amide
  参考文献：
  名称：

  MIYAKEH, AKIO;KAVAI, TATSUXIKO;JOSIMURA, JOSINOBU

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-丙烷磺内酯 生成 3-iodopropanesulphonamide
  参考文献：
  名称：

  Helberger,J.H.; Sproviero,J.F., Justus Liebigs Annalen der Chemie, 1963, vol. 666, p. 67 - 74

  摘要：

  DOI：

文献信息

• Novel carbapenem derivatives of quarternary salt type
  申请人：——

  公开号：US20030022881A1

  公开（公告）日：2003-01-30

  An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: 1 wherein R 1 represents H or methyl; R 2 and R 3 each independently represent H, halogen, lower alkyl or the like; R 4 represents optionally substituted lower alkylthio or the like; and R 5 represents optionally substituted lower alkyl or the like.

  本发明的目的在于提供对MRSA、PRSP、流感病毒和β-内酰胺酶产生菌具有强大抗生素活性的碳青霉烯衍生物，且对DHP-1稳定。根据本发明的化合物是由公式(I)表示的化合物或其药物可接受的盐：1其中R1代表H或甲基；R2和R3各自独立地代表H、卤素、低级烷基等；R4代表可选地取代的低级烷基亚磺酰基等；R5代表可选地取代的低级烷基等。
• Triazolopyridazine compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05389633A1

  公开（公告）日：1995-02-14

  Novel compound represented by the formula: ##STR1## wherein R.sup.1 stands for H, an optionally substituted lower alkyl group or a halogen; R.sup.2 and R.sup.3 respectively stands for a hydrogen or an optionally substituted lower alkyl group, or R.sup.2 and R.sup.3 may, taken together with the adjacent --C.dbd.C-- group, form a 5- to 7-membered ring; X stands for O, SO or SO.sub.2 ; Y stands for a group of the formula: ##STR2## (R.sup.4 and R.sup.5 respectively stand for H or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R.sup.6 and R.sup.7 each stands for H, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R.sup.6 and R.sup.7 may, taken together with the adjacent N, form an optionally substituted N-containing heterocyclic group; m stands for 0 to 4; n stands for 0 to 4, or a salt thereof, which has excellent anti-PAF activities anti-LTC.sub.4 activities and anti-ET-1 activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmasceutical compositions.

  由以下公式表示的新型化合物：##STR1## 其中 R.sup.1 代表 H，一个可选地取代的低级烷基团或一个卤素；R.sup.2 和 R.sup.3 分别代表一个氢或一个可选地取代的低级烷基团，或者 R.sup.2 和 R.sup.3 可以与相邻的 --C.dbd.C-- 基团一起形成一个 5 至 7 成员的环；X 代表 O, SO 或 SO.sub.2 ；Y 代表一个由以下公式表示的基团：##STR2## （R.sup.4 和 R.sup.5 分别代表 H 或一个可选地取代的低级烷基团）或一个由一个可选地取代的 3 至 7 成员的同环或杂环派生的二价基团；R.sup.6 和 R.sup.7 各自代表 H，一个可选地取代的低级烷基团，一个可选地取代的环烷基团或一个可选地取代的芳香基团，或者 R.sup.6 和 R.sup.7 可以与相邻的 N 一起形成一个可选地取代的含 N 杂环基团；m 代表 0 至 4；n 代表 0 至 4，或其盐，具有极好的抗-PAF 活性、抗-LTC.sub.4 活性和抗-ET-1 活性，作为抗哮喘剂具有价值，及其生产、中间体和药物组合物。
• Pyridazine compounds, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05369104A1

  公开（公告）日：1994-11-29

  Novel compound represented by the formula: ##STR1## wherein X stands for a methine (i.e. the group --CH.dbd.) group or a nitrogen atom; R.sup.1 stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R.sup.2 and R.sup.3 respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, or, taken together, may form a 5- to 7-membered ring combined with the adjacent --C.dbd.C--; R.sup.4 and R.sup.5 respectively stands for a hydrogen atom or an optionally substituted lower alkyl group or, taken together, form a 3- to 7-membered homo- or heterocyclic ring combined with the adjacent carbon atom; A stands for an optionally substituted amino group; m and n denote 1 to 4, respectively, or salts thereof which has an antiallergic, antiinflammatory and anti-PAF activity and is useful as an antiasthmatic agent.

  化合物的结构式为：##STR1## 其中 X 代表一个甲烷基（即--CH.dbd.）基团或一个氮原子；R.sup.1 代表一个氢原子，一个可选择取代的低烷基基团或一个卤素原子；R.sup.2 和 R.sup.3 分别代表一个氢原子或一个可选择取代的低烷基基团，或者结合在一起，可以与相邻的--C.dbd.C--形成一个5-到7-成员环；R.sup.4 和 R.sup.5 分别代表一个氢原子或一个可选择取代的低烷基基团，或者结合在一起，可以与相邻的碳原子形成一个3-到7-成员同源或异源环；A 代表一个可选择取代的氨基基团；m 和 n 分别表示1到4，或其盐，具有抗过敏、抗炎和抗PAF活性，可用作抗哮喘药物。
• Imidazopyridazines and use as antiasthmatic agents
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05155108A1

  公开（公告）日：1992-10-13

  The imidazo[1,2-b]pyridazine compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R.sub.2 an R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)n (n=0 to 2), Alk is a straight or branched chain alkylene group containing 1-10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.

  式中imidazo [1,2-b] pyridazine化合物：##STR1## 其中R.sub.1是氢原子或卤素原子，或是具有取代基的低烷基，R.sub.2和R.sub.3分别是氢原子，具有取代基的低烷基，环烷基或苯基，或者R.sub.2和R.sub.3与它们键合的相邻氮原子一起可以形成具有取代基的杂环，X是氧原子或S（O）n（n = 0至2），Alk是含有1-10个碳原子的直链或支链烷基，也可以具有取代基，或其药学上可接受的盐，具有抗过敏，抗炎和抗PAF活性，以及其生产和使用。
• Imidazopyridazines
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05202324A1

  公开（公告）日：1993-04-13

  The imidazo[1,2-b]pyridazine compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, or a lower alkyl group optionally having substituent(s), R.sub.2 and R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O).sub.n (n=0 to 2), Alk is a straight or branched chain alkylene group containing 1-10 carbon atoms and optionally having substituent(s), or their pharmaceutically acceptable salts which possess antiallergic, anti-inflammatory and anti-PAF activities, and their production and use.

  式为：##STR1##的咪唑并[1,2-b]吡嗪化合物，其中R.sub.1是氢原子或卤素原子，或是具有取代基的低碳基，R.sub.2和R.sub.3是独立的氢原子，具有取代基的低碳基，环烷基或苯基，或R.sub.2和R.sub.3与它们所键合的相邻氮原子一起可以形成具有取代基的杂环，X是氧原子或S(O).sub.n（n = 0到2），Alk是含有1-10个碳原子的直链或支链烷基，并且可以具有取代基，或其药学上可接受的盐，具有抗过敏，抗炎和抗PAF活性，以及它们的生产和使用。