4-phenyl-1,2,4-triazoline-3,5-dione | 86365-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-phenyl-1,2,4-triazoline-3,5-dione
• 英文别名: 4-(3,5-Dioxo-1,2,4-triazol-4-yl)benzenesulfonic acid
• CAS: 86365-16-4
• 化学式: C₈H₅N₃O₅S
• 分子量: 255.211
• InChiKey: OGYRAHDRPMEMIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-phenyl-1,2,4-triazoline-3,5-dione 、 天然橡胶 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-(4-Sulfophenyl)-5,8-dihydro-6-methyl-1H-<1,2,4>triazolo<1,2-a>pyridazine-1,3(2H)-dione
  参考文献：
  名称：

  Potent hydrophilic dienophiles. Synthesis and aqueous stability of several 4-aryl- and sulfonated 4-aryl-1,2,4-triazoline-3,5-diones and their immobilization on silica gel

  摘要：

  DOI：

  10.1021/jo00164a005
• 作为产物：
  描述：

  4-苯基脲唑 在 氯磺酸 、 水 、 dinitrogen tetraoxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.08h， 生成 4-phenyl-1,2,4-triazoline-3,5-dione
  参考文献：
  名称：

  Potent hydrophilic dienophiles. Synthesis and aqueous stability of several 4-aryl- and sulfonated 4-aryl-1,2,4-triazoline-3,5-diones and their immobilization on silica gel

  摘要：

  DOI：

  10.1021/jo00164a005

文献信息

• METHODS AND KITS FOR DETECTING FUNGAL INFECTION
  申请人：Semorex Inc.

  公开号：US20160313356A1

  公开（公告）日：2016-10-27

  Methods and kits which utilize a conjugate, preferably an adduct, of ergosterol for determining the presence or level of a broad spectrum of ergosterol-containing organisms (e.g., fungi) in various substrates are disclosed. These methods and kits can be used to accurately and efficiently diagnose a subject having a fungal infection, particularly invasive fungal infection, and to accurately and efficiently detect the presence of fungi and other ergosterol-containing organisms in other substrates. Antibodies and other compounds (e.g., molecularly imprinted polymers) that are capable of selectively binding to ergosterol or to an ergosterol-containing conjugate and methods of producing same are also disclosed.