N6-isopropyl-D-lysine | 147489-94-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N6-isopropyl-D-lysine
• 英文别名: (2R)-2-amino-6-(propan-2-ylamino)hexanoic acid
• CAS: 147489-94-9
• 化学式: C₉H₂₀N₂O₂
• 分子量: 188.27
• InChiKey: CBAWNLIZBXJSFS-MRVPVSSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Quinoline potassium channel inhibitors
  申请人：Dinsmore J. Christopher

  公开号：US20070043042A1

  公开（公告）日：2007-02-22

  The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

  本发明涉及具有结构（I）的化合物，其作为钾通道抑制剂用于治疗心律失常等。
• Method For Elevating Prolactin in Mammals
  申请人：Menzaghi Frederique

  公开号：US20090312271A1

  公开（公告）日：2009-12-17

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• N-Oxides of Kappa Receptor Peptides
  申请人：Junien Jean-Louis

  公开号：US20100029575A1

  公开（公告）日：2010-02-04

  Certain peptides which exhibit high selectivity for the kappa opioid receptor (KOR) versus the mu opioid receptor and little or no CYP3A4 inhibitory activity including tetrapeptides of four D-isomer amino acid residues having a C-terminus which is an N-oxide-substituted amide such, as H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-picolyl-N-oxide. A preferred compound, which has an affinity for the KOR at least 1,000 times its affinity for the mu opioid receptor and an IC50 for CYP3 A4 of greater than about 10 micromolar, is H-D-Phe-D-Phe-D-Nle-D-Arg-NH-4-picolyl-N-oxide
• Method For Elevating Prolactin In Mammals
  申请人：Menzaghi Frederique

  公开号：US20130012431A1

  公开（公告）日：2013-01-10

  Methods for elevating and stabilizing prolactin levels in a mammal including methods of treating disorders and conditions associated with reduced serum levels of prolactin are provided. Also provided are methods of using certain synthetic tetrapeptide amides which are peripherally selective kappa opioid receptor agonists to elevate or stabilize serum prolactin levels.
• US7692017B2
  申请人：——

  公开号：US7692017B2

  公开（公告）日：2010-04-06