1-Piperazineacetic acid, I+/-,I+/--dimethyl-4-(1-methylethyl)- | 1251334-10-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Piperazineacetic acid, I+/-,I+/--dimethyl-4-(1-methylethyl)-
• 英文别名: 2-methyl-2-(4-propan-2-ylpiperazin-1-yl)propanoic acid
• CAS: 1251334-10-7
• 化学式: C₁₁H₂₂N₂O₂
• 分子量: 214.3
• InChiKey: HSVXFNVDAUWXAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Sulfonamide-substituted chalcone derivatives and their use to treat diseases
  申请人：Worsencroft J. Kimberly

  公开号：US20070093453A1

  公开（公告）日：2007-04-26

  The invention relates to compounds, pharmaceutical compositions and methods of using compounds of the general formula or its pharmaceutically acceptable salt or ester, wherein the substituents are defined in the application.

  本发明涉及一般式化合物、药物组合物以及使用该化合物的方法，或其药学上可接受的盐或酯，其中取代基在申请中定义。
• USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER
  申请人：Asana Biosciences, LLC

  公开号：US20170157126A1

  公开（公告）日：2017-06-08

  Disclosed are methods of treating cancer, which include administering a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt or ester thereof, to a subject in need thereof. Also disclosed are methods of inhibiting growth and proliferation of cancer cells in vitro or in vivo, which include contacting the cells with an amount of the compound of formula (I) effective to inhibit the growth or proliferation of the cancer cells. Further disclosed are methods of inhibiting tumor growth, which include contacting the tumor with an amount of the compound of formula (I) effective to inhibit the growth of the tumor.
• US7173129B2
  申请人：——

  公开号：US7173129B2

  公开（公告）日：2007-02-06