4-n-Pentylprolin | 40282-37-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-n-Pentylprolin
• 英文别名: 4-Pentylprolin；4-pentyl-pyrrolidine-2-carboxylic acid；4-Pentylproline；4-pentylpyrrolidine-2-carboxylic acid
• CAS: 40282-37-9
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: SWBGPJIGJIFMFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Novel lincomycin derivatives possessing antimicrobial activity
  申请人：Lewis G. Jason

  公开号：US20050043248A1

  公开（公告）日：2005-02-24

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  新型的林可霉素衍生物被披露。这些林可霉素衍生物表现出抗菌活性。本发明的化合物可能对细菌，包括革兰氏阳性生物，表现出强效活性，并且可能是有用的抗微生物药剂。该化合物的合成和使用方法也被披露。
• Novel lincomycin derivatives possessing antibacterial activity
  申请人：Lewis G. Jason

  公开号：US20050215488A1

  公开（公告）日：2005-09-29

  Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. The compounds of the subject invention may exhibit potent activities against bacteria, including Gram positive organisms, and may be useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

  新型的林可霉素衍生物已被披露。这些林可霉素衍生物表现出抗菌活性。本发明的化合物可能对细菌，包括革兰氏阳性生物，表现出强效活性，并可能是有用的抗微生物药剂。该化合物的合成和使用方法也已被披露。
• [EN] MODULATION OF TISSUE TRANSGLUTAMINASE ACTIVATION IN DISEASE<br/>[FR] MODULATION DE L'ACTIVATION DE LA TRANSGLUTAMINASE TISSULAIRE DANS UNE MALADIE
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2015116846A1

  公开（公告）日：2015-08-06

  Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activity of TG2 associated with inflammatory disorders, which disorders may include, without limitation, sepsis, ischemic reperfusion injury, renal fibrosis, and the like.

  提供了调节组织转谷氨酰胺酶（TG2）生理活化的组合物和方法；这些方法可以包括抑制与炎症性疾病相关的TG2活性，这些疾病可能包括但不限于败血症、缺血再灌注损伤、肾脏纤维化等。
• Modulation of tissue transglutaminase activation in disease
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US10010541B2

  公开（公告）日：2018-07-03

  Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activity of TG2 associated with inflammatory disorders, which disorders may include, without limitation, sepsis, ischemic reperfusion injury, renal fibrosis, and the like.

  提供了调节组织转谷氨酰胺酶（TG2）生理活化的组合物和方法；这些方法可包括抑制与炎症性疾病相关的 TG2 的活性，这些疾病可包括但不限于败血症、缺血再灌注损伤、肾脏纤维化等。
• NOVEL LINCOMYCIN DERIVATIVES POSSESSING ANTIMICROBIAL ACTIVITY
  申请人：Vicuron Pharmaceuticals, Inc.

  公开号：EP1644393A2

  公开（公告）日：2006-04-12