(4AS,8aS)-6-methyloctahydro-1H-pyrido[3,4-b][1,4]oxazine | 1330763-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (4AS,8aS)-6-methyloctahydro-1H-pyrido[3,4-b][1,4]oxazine
• 英文别名: (4aS,8aS)-6-methyl-1,2,3,4a,5,7,8,8a-octahydropyrido[3,4-b][1,4]oxazine
• CAS: 1330763-35-3
• 化学式: C₈H₁₆N₂O
• 分子量: 156.23
• InChiKey: KIWLWZVAJKNLOX-YUMQZZPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SOMATOSTATIN MODULATORS AND USES THEREOF
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US20180016252A1

  公开（公告）日：2018-01-18

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

  本文描述了一些肽类调节剂化合物，制备这类化合物的方法，包含这类化合物的药物组合物和药物，以及利用这类化合物治疗需要调节生长抑素活性的疾病、症状或疾病的方法。
• Somatostatin modulators and uses thereof
  申请人：Crinetics Pharmaceuticals, Inc.

  公开号：US10351547B2

  公开（公告）日：2019-07-16

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.

  本文描述了作为体生长抑素调节剂的化合物、制造此类化合物的方法、包含此类化合物的药物组合物和药剂，以及使用此类化合物治疗可受益于体生长抑素活性调节的病症、疾病或紊乱的方法。
• US9896432B2
  申请人：——

  公开号：US9896432B2

  公开（公告）日：2018-02-20
• [EN] SOMATOSTATIN MODULATORS AND USES THEREOF<br/>[FR] MODULATEURS DE LA SOMATOSTATINE ET LEURS UTILISATIONS
  申请人：CRINETICS PHARMACEUTICALS INC

  公开号：WO2018013676A1

  公开（公告）日：2018-01-18

  Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.
• [EN] SOMATOSTATIN MODULATORS FOR TREATING PITUITARY ADENOMAS<br/>[FR] MODULATEURS DE SOMATOSTATINE POUR LE TRAITEMENT D'ADÉNOMES PITUITAIRES
  申请人：CRINETICS PHARMACEUTICALS INC

  公开号：WO2021076448A1

  公开（公告）日：2021-04-22

  Described herein are compounds that are somatostatin modulators, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders that would benefit from modulation of somatostatin activity.