Aceroside X | 130233-82-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: Aceroside X
• 英文别名: 1-(4-hydroxyphenyl)-7-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]heptan-3-one
• CAS: 130233-82-8
• 化学式: C₂₅H₃₂O₈
• 分子量: 460.524
• InChiKey: BLDFXKZUHJNHED-NHTNDUFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  137
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 作用下， 反应 1.0h， 以10 mg的产率得到Aceroside X
  参考文献：
  名称：

  Studies on the constituents of aceraceae plants. VII. Diarylheptanoids from Acer griseum and Acer triflorum.

  摘要：

  一种名为aceroside IX (1) 的二苯庚烷类糖苷，化学式为C30H40O12, [α]D -63.5°，从灰背枫 (Acer griseum) 和三花枫 (A. triflorum) 的树皮中分离得到。另一种名为aceroside X (2) 的二苯庚烷类糖苷，化学式为C25H31O8，熔点121°， [α]21D -29.7°，以及表儿茶素，从灰背枫的树皮中分离得到，并通过薄层色谱在三花枫中检测到。在酸水解后，1生成了一种新的二苯庚烷类化合物acerogenin G (3)，化学式为C19H22O3，经过鉴定为(-)-centrolobol (5) 的酮衍生物，并产生葡萄糖和阿比糖。在部分水解过程中，1得到aceroside X (2) 和阿比糖。通过对3及其单甲基醚 (6) 的质谱分析结果，发现aceroside IX 的糖基通过与acerogenin G (3) 的C-4"位点的酚羟基结合。后者通过对1进行甲基化后酸水解生成。根据碳-13核磁共振谱分析，并与aceroside VIII (7) 的谱图比较，确定acerosides (1) 和X (2) 分别为acerogenin G 的4"-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside 和4"-O-β-D-glucopyranoside。

  DOI：

  10.1248/cpb.38.1506

文献信息

• PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF BONE DISEASE, FUNCTIONAL FOOD OR HEALTH FOOD COMPRISING THE COMPOSITION, AND PHARMACEUTICAL PREPARATION COMPRISING THE COMPOSITION AS ACTIVE INGREDIENT
  申请人：Akihisa, Toshihiro

  公开号：EP2050442A1

  公开（公告）日：2009-04-22

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)

  本发明提供了一种用于预防和/或治疗骨病的高安全性药物组合物、由其组成的药物制剂、由其组成的保健食品、由其组成的功能性食品。由于本发明包含下式（I）所示的芳基庚烷类化合物及其衍生物，因此能够预防和/或治疗骨病。 (在式(I)中，R1和R5是选自氢原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R2、R3和R4是选自氢原子、氧原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R5可与另一芳基的庚基在元位置上结合形成环)。
• Pharmaceutical composition for prevention and/or treatment of bone disease, functional food or health food comprising the composition, and pharmaceutical preparation comprising the composition as active ingredient
  申请人：Akihisa, Toshihiro

  公开号：EP2407160A1

  公开（公告）日：2012-01-18

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R1 and R5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R2, R3, and R4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)

  本发明提供了一种用于预防和/或治疗骨病的高安全性药物组合物、由其组成的药物制剂、由其组成的保健食品、由其组成的功能性食品。由于本发明包含下式（I）所示的芳基庚烷类化合物及其衍生物，因此能够预防和/或治疗骨病。 (在式(I)中，R1和R5是选自氢原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R2、R3和R4是选自氢原子、氧原子、碳原子数为1至3的烷基、单糖和二糖的官能团；R5可与另一芳基的庚基在元位置上结合形成环)。
• NAGAI, MASAHIRO;MATSUDA, ERIKO;INOUE, TAKAO;FUJITA, MASAO;CHI, HYUNG JOON+, CHEM. AND PHARM. BULL., 38,(1990) N, C. 1506-1508
  作者：NAGAI, MASAHIRO、MATSUDA, ERIKO、INOUE, TAKAO、FUJITA, MASAO、CHI, HYUNG JOON+

  DOI：——

  日期：——
• PHARMACEUTICAL COMPOSITION FOR PREVENTING AND/OR TREATING BONE DISEASE, FUNCTIONAL FOOD OR HEALTH FOOD AND PHARMACEUTICAL PREPARATION COMPRISING THEREOF AS ACTIVE INGREDIENT
  申请人：Woo Je-Tae

  公开号：US20090227527A1

  公开（公告）日：2009-09-10

  The present invention provides a highly safe pharmaceutical composition for preventing and/or treating bone disease, a pharmaceutical preparation comprising thereof, a health food comprising thereof, a functional food comprising thereof. Since the present invention comprises the arylheptanoid compound shown in the following formula (I) and the derivatives thereof, it enables to prevent and/or treat the bone disease. (In the formula (I), R 1 and R 5 are a functional group selected from the group consisting of a hydrogen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R 2 , R 3 , and R 4 are a functional group selected from the group consisting of a hydrogen atom, an oxygen atom, alkyl group having carbon numbers 1 to 3, monosaccharide and disaccharide; R 5 may be bound on meta-position against heptylene group of another aryl group to form a ring.)
• US8822705B2
  申请人：——

  公开号：US8822705B2

  公开（公告）日：2014-09-02