2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[1S-methyl-2-(4-{pyrrolidin-1-ylcarbonylmethyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole | 666852-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[1S-methyl-2-(4-{pyrrolidin-1-ylcarbonylmethyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole
• 英文别名: 2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[1S-methyl-2-(4-{pyrrolidin-1-ylcarbonylmethyl}piperazin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole；1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-[5-(3,5-dimethylphenyl)-4-[(2S)-1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]propan-2-yl]-6H-thieno[2,3-b]pyrrol-2-yl]-2-methylpropan-1-one
• CAS: 666852-29-5
• 化学式: C₃₇H₅₁N₅O₂S
• 分子量: 629.91
• InChiKey: YRUMBQOTAKNNPZ-CSJMBUEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  91.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(7-azabicyclo[2.2.1]heptan-7-yl)-2-[5-(3,5-dimethylphenyl)-6-(4-methylphenyl)sulfonyl-4-[(2S)-1-[4-(2-oxo-2-pyrrolidin-1-ylethyl)piperazin-1-yl]propan-2-yl]thieno[2,3-b]pyrrol-2-yl]-2-methylpropan-1-one 在 magnesium 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以61%的产率得到2-[1,1-dimethyl-2-oxo-2-azabicyclo[2.2.1]heptan-7-ylethyl]-4-[1S-methyl-2-(4-{pyrrolidin-1-ylcarbonylmethyl}piperidin-1-yl)ethyl]-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrole
  参考文献：
  名称：

  [EN] 6H-THIENO`2, 3-B!PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
  [FR] DERIVES DE 6H-THIENO`2,3-B!PYRROLE EN TANT QU'ANTAGONISTES DE LA GONADOLIBERINE (GNRH)

  摘要：

  这项发明涉及一组新型噻吩-吡咯烷化合物的化学式（I）：其中：R1、R2、R3、R4和R5如规范中定义，这些化合物可用作促性腺激素释放激素拮抗剂。该发明还涉及所述化合物的药物配方、使用所述化合物的治疗方法以及所述化合物的制备方法。

  公开号：

  WO2004018480A1

文献信息

• 6H-THIENO[2,3-b]PYRROLE DERIVATIVES AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE (GNRH)
  申请人：Foote Michael Kevin

  公开号：US20080045517A1

  公开（公告）日：2008-02-21

  The invention relates to a group of novel thieno-pyrrole compounds of Formula (I): wherein: R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, which are useful as gonadotrophin releasing hormone antagonists. The invention also relates to pharmaceutical formulations of said compounds, methods of treatment using said compounds and to processes for the preparation of said compounds.

  该发明涉及一组新型噻吩-吡咯化合物，其化学式为(I)：其中：R1、R2、R3、R4和R5如规范中所定义，这些化合物可用作促性腺激素释放激素拮抗剂。该发明还涉及该化合物的制药配方、使用该化合物的治疗方法以及制备该化合物的过程。
• Polymer particle dispersion, cosmetic compositions comprising it and cosmetic process using it
  申请人：Farcet Celine

  公开号：US20060194932A1

  公开（公告）日：2006-08-31

  The present disclosure relates to a cosmetic composition comprising, in a cosmetically acceptable medium, at least one dispersion of polymer particles in a liquid silicone medium, the polymer being a copolymer comprising at least one first block that is soluble and at least one second block that is insoluble in the silicone medium. Another aspect of the present disclosure relates to a dispersion of polymer particles in a liquid silicone medium, and also to a cosmetic process for making up, cleansing, protecting against the sun, shaping, dyeing or caring for keratin materials, such as the body or facial skin, the nails, the hair and/or the eyelashes, and for use with the present composition.

  本公开涉及一种化妆品组合物，该组合物在一种化妆品可接受的介质中，包含至少一种在液态硅酮介质中的聚合物颗粒分散体，该聚合物是一种共聚物，包含至少一种可溶于硅酮介质的第一嵌段和至少一种不溶于硅酮介质的第二嵌段。本公开的另一方面涉及一种聚合物颗粒在液态硅酮介质中的分散体，还涉及一种用于妆容、清洁、防晒、塑形、染色或护理角蛋白材料（如身体或面部皮肤、指甲、头发和/或睫毛）的化妆品工艺，以及与本组合物一起使用。
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