Octadecylglycerol | 38718-97-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Octadecylglycerol
• 英文别名: henicosane-1,2,3-triol
• CAS: 38718-97-7
• 化学式: C₂₁H₄₄O₃
• 分子量: 344.6
• InChiKey: FLYFLESWJKLOMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  24
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• LIPOHILLIC OLIGONUCLEOTIDE ANALOGS
  申请人：MILTENYI BIOTEC GMBH

  公开号：US20160017325A1

  公开（公告）日：2016-01-21

  Lipophilic oligonucleotide comprising a phosphate glycerol unit containing at least one aliphatic unsaturated carbon bond according to formula (I), with Oligonucleotide an unmodified or modified nucleic acid of 2-1000 nucleotides in length R=a bond or a linker unit Y═OH, SH or NHR3 X and Z=independently O, S or NR3 R3=hydrogen or branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkyl aryl residue with 10 to 30 carbon atoms R1, R2 branched or unbranched and/or substituted or unsubstituted alkyl, aryl and/or alkylaryl residue with 10 to 30 carbon atoms, with the provisio that at least one of the residues R1 or R2 comprises at least one aliphatic carbon-carbon double bond Use of lipophilic oligonucleotide according to Formula I for drug discovery or for transfection of cells.

  含有至少一个脂肪族不饱和碳键的磷酸甘油单元的亲脂性寡核苷酸，其根据式（I）定义，其中，寡核苷酸是长度为2-1000个核苷酸的未修饰或修饰的核酸，R=键或连接单元，Y═OH、SH或NHR3，X和Z=独立的O、S或NR3，R3=氢或带有10至30个碳原子的支链或非支链和/或取代或未取代的烷基、芳基和/或烷基芳基残基，R1、R2=带有10至30个碳原子的支链或非支链和/或取代或未取代的烷基、芳基和/或烷基芳基残基，但至少其中一个残基R1或R2包含至少一个脂肪族碳-碳双键。将式（I）中的亲脂性寡核苷酸用于药物发现或细胞转染。
• RNAi Modulation of APOB and Uses Thereof
  申请人：Soutschek Juergen

  公开号：US20100216866A1

  公开（公告）日：2010-08-26

  The invention relates to compositions and methods for modulating the expression of apolipoprotein B, and more particularly to the downregulation of apolipoprotein B by chemically modified oligonucleotides.

  该发明涉及调节载脂蛋白B表达的组合物和方法，更具体地，涉及通过化学修饰寡核苷酸下调载脂蛋白B的表达。
• LIGAND-CONJUGATED MONOMERS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20130184328A1

  公开（公告）日：2013-07-18

  This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression.

  本发明涉及组成物和方法，用于制备和使用化学修饰的寡核苷酸代理，以抑制基因表达。
• Concentrated liquid fabric softener containing mixed active system
  申请人：Procter & Gamble European Technical Center

  公开号：EP0000406A1

  公开（公告）日：1979-01-24

  Concentrated liquid fabric softening compositions containing a fabric substantive agent, selected from poly- ammonium and alkylpyridinium salts and mixtures thereof, in conjunction with a fabric softening component, selected from quaternary ammonium salts, alkylimidazolinium salts, fatty esters, fatty ethers, and fatty compounds containing a sulfur atom or nitrogen amide linking group and mixtures thereof, together with a liquid carrier. The weight of the fabric-substantive agent to the fabric-softening component is in the range from about 6:1 to about 1:4. The subject concentrated softener compositions are easily dispersible in aqueous medium and thus can evenly deposit onto fibers to thereby provide textile handling benefits inclusive of softening, static control, ease-of-ironing, fluffiness, pliability and smoothness.

  浓缩的液态织物柔软组合物，含有一种选自聚铵盐和烷基吡啶鎓盐及其混合物的织物固化剂，与一种选自季铵盐、烷基咪唑啉鎓盐、脂肪酯、脂肪醚和含有硫原子或氮酰胺连接基团及其混合物的脂肪化合物的织物柔软组分，以及一种液态载体。织物柔顺剂与织物柔顺成分的重量比为约 6:1 至约 1:4。该浓缩柔软剂组合物易于在水性介质中分散，因此可以均匀地沉积在纤维上，从而提供织物处理方面的优势，包括柔软、静电控制、易熨烫、蓬松、柔韧和平滑。
• New 1,3-dioxolan-4-yl derivatives of 2-picolylamine
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0388950A2

  公开（公告）日：1990-09-26

  The present invention relates to new 1,3-dioxolan-4-yl derivatives of 2-picolylamine having the formula (I): wherein: R₁ represents an alkyl or phenylalkyl radical; R₂ represents hydrogen, C₁-C₄-­acyl or C₁-C₄-alkoxycarbonyl; R₃ is either an electron pair, in which case t means nothing and q is zero, or R₃ is hydrogen or C₁-C₄-alkyl, in which case t is (+) and q=1; X is a single bond, an oxygen atom or a carbamoyloxy group; A⁻ is a pharmaceutically acceptable anion. These compounds are PAF antagonists and, consequently, useful in the treatment of the diseases in which this substance is involved.

  本发明涉及具有式 (I) 的 2-环戊胺的 1,3-二氧戊环-4-基新衍生物： 其中： R₁ 代表烷基或苯基烷基；R₂ 代表氢、C₁-C₄-酰基或 C₁-C₄- 烷氧基羰基； R₃ 是电子对，在这种情况下，t 表示无，q 为零，或者 R₃ 是氢或 C₁-C₄ 烷基，在这种情况下，t 为 (+)，q=1；X 是单键、氧原子或氨基甲酰氧基；A- 是药学上可接受的阴离子。 这些化合物是 PAF 拮抗剂，因此可用于治疗与 PAF 有关的疾病。