1-(N-pyrid-2-ylmethyl)-6-(tert-butoxycarbonylamino)hexanamide | 346693-19-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-(N-pyrid-2-ylmethyl)-6-(tert-butoxycarbonylamino)hexanamide
• 英文别名: tert-butyl N-[6-oxo-6-(pyridin-2-ylmethylamino)hexyl]carbamate
• CAS: 346693-19-4
• 化学式: C₁₇H₂₇N₃O₃
• 分子量: 321.42
• InChiKey: OMGXMDXOSFBLRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  80.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(N-pyrid-2-ylmethyl)-6-(tert-butoxycarbonylamino)hexanamide 在 三氟乙酸 作用下， 以 水 为溶剂， 反应 1.0h， 生成 1-(N-pyrid-2-ylmethyl)-6-aminohexanamide
  参考文献：
  名称：

  Molecular design of the polymer forming the complex with metal. Part IV. Complexation of pyridine-containing polyisoprene with zinc

  摘要：

  Two types of polyisoprenes modified by N-pyrid-2-ylmethyl amide (MPY) group were synthesized, and their complexation with ZnCl2 and the thermal property of complexes were investigated. Although these polymers are viscous liquid, the complex is solid at room temperature. MPY modified polyisoprene in which MPY connected a main chain without a spacer (MPYIP) shows the non-stoichiometric complexation, so that the melting temperature of the complex is low (105 degreesC). On the other hand, MPY modified polyisoprene with a C5 spacer (MPYC5IP) shows the high melting temperature (143 degreesC), It is surprising that the glass-transition temperatures of the complexes are almost as same as that of polyisoprene. These results indicate that the presence of the spacer effectively enhances the aggregation of polymers. As a result, MPY is a novel functional structure, since MPY-ZnCl2 complex functions as an excellent hard-segment in various flexible polymers. (C) 2001 Elsevier Science B,V. All rights reserved.

  DOI：

  10.1016/s0022-2860(00)00961-3
• 作为产物：
  描述：

  2-(叔丁氧羰基氧亚氨基)-2-苯乙腈 在 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 水 、 乙酸乙酯 为溶剂， 反应 53.0h， 生成 1-(N-pyrid-2-ylmethyl)-6-(tert-butoxycarbonylamino)hexanamide
  参考文献：
  名称：

  Molecular design of the polymer forming the complex with metal. Part IV. Complexation of pyridine-containing polyisoprene with zinc

  摘要：

  Two types of polyisoprenes modified by N-pyrid-2-ylmethyl amide (MPY) group were synthesized, and their complexation with ZnCl2 and the thermal property of complexes were investigated. Although these polymers are viscous liquid, the complex is solid at room temperature. MPY modified polyisoprene in which MPY connected a main chain without a spacer (MPYIP) shows the non-stoichiometric complexation, so that the melting temperature of the complex is low (105 degreesC). On the other hand, MPY modified polyisoprene with a C5 spacer (MPYC5IP) shows the high melting temperature (143 degreesC), It is surprising that the glass-transition temperatures of the complexes are almost as same as that of polyisoprene. These results indicate that the presence of the spacer effectively enhances the aggregation of polymers. As a result, MPY is a novel functional structure, since MPY-ZnCl2 complex functions as an excellent hard-segment in various flexible polymers. (C) 2001 Elsevier Science B,V. All rights reserved.

  DOI：

  10.1016/s0022-2860(00)00961-3

文献信息

• A Synthesis of <i>N</i>-Bridged 5,6-Bicylic Pyridines via A Mild Cyclodehydration Using the Burgess Reagent and Discovery of A Novel Carbamylsulfonylation Reaction
  作者：Jie Jack Li、James J. Li、Jun Li、Ashok K. Trehan、Henry S. Wong、Subramanian Krishnananthan、Lawrence J. Kennedy、Qi Gao、Alicia Ng、Jeffrey A. Robl、Balu Balasubramanian、Bang-Chi Chen

  DOI：10.1021/ol8011748

  日期：2008.7.3

  Cyclodehydration using the Burgess reagent provided a novel approach toward the synthesis of N-bridged 5,6-bicylic pyridines including pyrolo-, imidazo-, and triazolopyridines under mild and neutral conditions. The methodology tolerates acid-sensitive functional groups. A novel addition product was observed between the resulting pyrrolo- or imidazopyridine and an additional equivalent of the Burgess reagent, producing the corresponding sulfonylcarbamate adduct.