9,10-difluoro-7-(4-hydroxy-2-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one | 1233097-57-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 9,10-difluoro-7-(4-hydroxy-2-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one
• CAS: 1233097-57-8
• 化学式: C₂₅H₁₂F₂O₆
• 分子量: 446.363
• InChiKey: UQNRSWMMLGWLIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 、 2,4,5-三氟苯甲醛 以 乙醇 为溶剂， 反应 48.0h， 以16%的产率得到9,10-difluoro-7-(4-hydroxy-2-oxochromen-3-yl)-7H-chromeno[3,2-c]chromen-6-one
  参考文献：
  名称：

  [EN] COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER
  [FR] COMPOSÉS À BASE DE COUMARINE

  摘要：

  公开号：

  WO2010075280A3

文献信息

• COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER
  申请人：Zhu Lei

  公开号：US20110306605A1

  公开（公告）日：2011-12-15

  Compounds including those of the Formula I where X, R 1 , R 2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.

  提供包括公式I中的化合物，其中X，R1，R2和下标t的定义如本文所述，这些化合物作为γ-分泌酶抑制剂有用，提供了包括这些化合物的组合物，以及使用这些化合物治疗或预防神经退行性疾病的方法，例如阿尔茨海默病。
• [EN] COUMARIN-BASED COMPOUNDS<br/>[FR] COMPOSÉS À BASE DE COUMARINE
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2010075280A2

  公开（公告）日：2010-07-01

  Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.
• [EN] COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER<br/>[FR] COMPOSÉS À BASE DE COUMARINE
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2010075280A3

  公开（公告）日：2010-08-19