Nα-stearoyl-lysine | 186832-73-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Nα-stearoyl-lysine
• 英文别名: n-Stearoyl lysine；6-amino-2-(octadecanoylamino)hexanoic acid
• CAS: 186832-73-5
• 化学式: C₂₄H₄₈N₂O₃
• 分子量: 412.657
• InChiKey: VWYVABSAUVXYNS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US20190077746A1

  公开（公告）日：2019-03-14

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料，通过用亲水材料共价修饰微/纳米材料表面获得的产品，以及制备这些产品的方法。表面上的微/纳米材料具有羧基或/和前羧基，这些羧基或前羧基被转化为它们的活性酯。通过在表面上的活性酯和修饰剂之间形成酰胺键，共价修饰的产品；其中修饰剂是带有一次和/或二次脂肪胺基的亲水化合物和/或亲水性聚合物。使用带有羧基和/或前羧基的单体来产生足够数量的羧基和/或前羧基，以便在待修饰的聚合物材料表面上形成。将羧基和/或前羧基转化为活性酯。使用合理大小的带有一次和/或二次胺基、带有带电离子和亲水性线性间隔臂的修饰剂来形成酰胺键，并获得共价修饰的表面层。
• Surface modification using N-acyl lysines
  申请人：AJINOMOTO CO., INC.

  公开号：EP0139481A2

  公开（公告）日：1985-05-02

  There is disclosed a formulation comprising a base component in combination with one or more organic component chosen from N-mono- and N,N-di-acylated basic amino acids, wherein the acyl group in the N-mono-acylated basic amino acid is an aliphatic acyl group having from 8 to 22 carbon atoms, and each of the acyl groups, which may be the same or different, in the N,N-di-acylated basic amino acid is an aliphatic acyl group having from 1 to 22 carbon atoms with the proviso that the two aliphatic acyl groups together have from 9 to 44 carbon atoms. The formulation is useful in novel cosmetics and as a novel surface-modified inorganic filler.

  本发明公开了一种制剂，该制剂由基质成分与一种或多种选自 N-单-和 N,N-二-酰化碱性氨基酸的有机成分组合而成，其中 N-单-酰化碱性氨基酸中的酰基是具有 8 至 22 个碳原子的脂肪族酰基、N,N-二乙酰化碱性氨基酸中的每个酰基（可以相同或不同）都是具有 1 至 22 个碳原子的脂肪族酰基，但这两个脂肪族酰基加在一起具有 9 至 44 个碳原子。 该配方可用于新型化妆品和新型表面改性无机填料。
• MICRO/NANOMATERIAL, PRODUCT THEREOF WITH SURFACE COVALENTLY MODIFIED WITH HYDROPHILIC MATERIAL, AND MANUFACTURING METHOD
  申请人：Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China

  公开号：EP3470443A1

  公开（公告）日：2019-04-17

  Disclosed are micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups. The carboxyl groups or/and pro-carboxyl groups are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. The method includes: using monomers bearing carboxyl groups and/or pro-carboxyl groups to generate an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified, then converting them into active esters; using a reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms to form amide bonds and obtain a covalently modified surface layer; regenerating active esters on the surface of a covalently modified product, then using the amide bond formation process to create multiple layers of covalent modification. High performance coating of the surface of a micro/nano material for negligible nonspecific adsorption is achieved with reasonably-sized hydrophilic modification agents.

  本发明公开了微纳米材料、通过亲水材料共价修饰微/纳米材料表面而获得的产品以及制造方法。微米/纳米材料表面具有羧基或/和原羧基。羧基或/和原羧基被转化为其活性酯。通过在表面上的活性酯和改性剂之间形成酰胺键，对产品进行共价改性；其中改性剂为亲水性化合物和/或亲水性聚合物，含有伯胺和/或仲脂族胺。该方法包括使用含有羧基和/或原羧基的单体，在待改性聚合物材料表面生成足够数量的羧基和/或原羧基，然后将其转化为活性酯；使用含有伯胺和/或仲胺、齐聚物和亲水线性间隔臂的合理大小的改性剂，形成酰胺键，获得共价改性表面层；在共价改性产品表面再生活性酯，然后使用酰胺键形成过程，形成多层共价改性层。通过合理大小的亲水改性剂，可实现微/纳米材料表面的高性能涂层，从而使非特异性吸附几乎可以忽略不计。
• HYDROPHOBIC ALGINIC ACID PARTICLE GROUP AND METHOD FOR PRODUCING SAME
  申请人：Nisshinbo Holdings Inc.

  公开号：EP3922666A1

  公开（公告）日：2021-12-15

  The present invention provides a hydrophobic alginic acid particle group which is obtained by subjecting a polyvalent metal alginate to a hydrophobization treatment, and which is configured such that the water absorption per 100 g of the particles is lower than the oil absorption per 100 g of the particles.

  本发明提供了一种疏水性海藻酸粒子群，它是通过对多价金属海藻酸盐进行疏水处理而获得的，其配置使得每 100 克粒子的吸水率低于每 100 克粒子的吸油量。
• Micro/nano materials, products obtained by covalently modifying surface of micro/nano materials with hydrophilic materials, and method for making same
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US10385013B2

  公开（公告）日：2019-08-20

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料、通过亲水材料共价改性微/纳米材料表面而获得的产品以及制造方法。微米/纳米材料表面具有羧基或/和原羧基，这些羧基可转化为活性酯。通过在表面上的活性酯和改性剂之间形成酰胺键，对产品进行共价改性；其中，改性剂是亲水性化合物和/或亲水性聚合物，带有伯胺和/或仲脂族胺。含有羧基和/或原羧基的单体用于在待改性聚合物材料表面产生足够数量的羧基和/或原羧基。羧基和/或原羧基被转化为活性酯。使用含有伯胺和/或仲胺、齐聚物和亲水性线性间隔臂的合理大小的改性剂来形成酰胺键，从而获得共价改性表层。