2-(2,4-dibenzyloxyphenyl)-6-benzyloxybenzofuran | 863310-54-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(2,4-dibenzyloxyphenyl)-6-benzyloxybenzofuran
• 英文别名: 2-[2,4-Bis(phenylmethoxy)phenyl]-6-phenylmethoxy-1-benzofuran
• CAS: 863310-54-7
• 化学式: C₃₅H₂₈O₄
• 分子量: 512.605
• InChiKey: VRPAXAJEDKDPPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  40.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2,4-dibenzyloxyphenyl)-6-benzyloxybenzofuran 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 2-(2,4-二羟基苯基)-6-羟基苯并呋喃
  参考文献：
  名称：

  A Short-step Convenient Synthesis of 2-Phenylbenzofuran from 3-Phenylcoumarin

  摘要：

  The reaction mechanism of chemical conversion of (E)-beta-[2-hydroxylphenylcthylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.

  DOI：

  10.3987/com-05-10424
• 作为产物：
  描述：

  (E)-β-[2-hydroxy-4-benzyloxyphenylethylene]-2,4-dibenzyloxybenzeneethanol 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 7.5h， 以60%的产率得到2-(2,4-dibenzyloxyphenyl)-6-benzyloxybenzofuran
  参考文献：
  名称：

  A Short-step Convenient Synthesis of 2-Phenylbenzofuran from 3-Phenylcoumarin

  摘要：

  The reaction mechanism of chemical conversion of (E)-beta-[2-hydroxylphenylcthylene]benzeneethanol into 2-phenylbenzofuran by DDQ, which involves loss of one carbon unit, was characterized and described. Five naturally occurring 2-phenylbenzofurans of not only the isoflavonoid but also stilbenoid origin were synthesized by use of this chemical scheme, which proved that this new scheme is a useful tool for quick synthesis of 2-phenylbenzofurans.

  DOI：

  10.3987/com-05-10424