(2S,3R)-4-amino-2-benzyl-3-benzoylbutan-1-ol hydrochloride | 1308348-26-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3R)-4-amino-2-benzyl-3-benzoylbutan-1-ol hydrochloride
• 英文别名: (2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol hydrochloride
• CAS: 1308348-26-6
• 化学式: C₁₈H₂₁NO₃*ClH
• 分子量: 335.831
• InChiKey: XCOWSOGHRKQGSY-QJHJCNPRSA-N

反应信息

• 作为反应物：
  描述：

  (2S,3R)-4-amino-2-benzyl-3-benzoylbutan-1-ol hydrochloride 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 49.0h， 以75%的产率得到(-)-(3R,4S)-3-benzyloxy-4-benzylpyrrolidine
  参考文献：
  名称：

  Hydrogenolysis of N-protected aminooxetanes over palladium: An efficient method for a one-step ring opening and debenzylation reaction

  摘要：

  An efficient method for the palladium mediated hydrogenation of an optically active, N-protected aminooxetane derivative has been developed. Using appropriate solvents, in a one-step reaction, a chiral 1,4-aminoalcohol derivative [(2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol] was formed over a Pd/C catalyst, during hydrogenolytic ring opening and debenzylation reactions. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.02.008
• 作为产物：
  描述：

  (-)-(2S,3S,1'S)-3-[1'-benzoyloxy-2'-(dibenzylamino)ethyl]-2-phenyloxetane 在 palladium 10% on activated carbon 、 氢气 作用下， 以 二氯甲烷 为溶剂， 45.0 ℃ 、1.0 MPa 条件下， 反应 24.0h， 以70%的产率得到(2S,3R)-4-amino-2-benzyl-3-benzoylbutan-1-ol hydrochloride
  参考文献：
  名称：

  Hydrogenolysis of N-protected aminooxetanes over palladium: An efficient method for a one-step ring opening and debenzylation reaction

  摘要：

  An efficient method for the palladium mediated hydrogenation of an optically active, N-protected aminooxetane derivative has been developed. Using appropriate solvents, in a one-step reaction, a chiral 1,4-aminoalcohol derivative [(2S,3R)-4-amino-3-benzoyloxy-2-benzylbutan-1-ol] was formed over a Pd/C catalyst, during hydrogenolytic ring opening and debenzylation reactions. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.02.008