3-hydroxy-2-(2-propen-1-yl)-4H-pyran-4-one | 56969-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3-hydroxy-2-(2-propen-1-yl)-4H-pyran-4-one
• 英文别名: 2-Allyl-3-hydroxy-4H-pyran-4-on；3-Hydroxy-2-allyl-4-pyron；2-allyl-3-hydroxy-pyran-4-one；3-Hydroxy-2-prop-2-enylpyran-4-one
• CAS: 56969-62-1
• 化学式: C₈H₈O₃
• 分子量: 152.15
• InChiKey: PCLDYYSRHOJRPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-Allyloxy-4H-pyran-4-on 以83%的产率得到
  参考文献：
  名称：

  LOOKER J. H.; BRANNIGAN L. H.; PROKOP R. J., J. HETEROCYCL. CHEM. , 1975, 12, NO 3, 537-540

  摘要：

  DOI：

文献信息

• Process for producing pyrid-4-ones
  申请人：THE ROYAL FREE HOSPITAL SCHOOL OF MEDICINE

  公开号：EP0335745A1

  公开（公告）日：1989-10-04

  Substituted-3-hydroxy-pyrid-4-ones, derivatives thereof, and salts thereof are produced by reacting subsituted-3-hydroxypyr-4-one with ammonia or a non-sterically hindered primary amine usually in the presence of a solvent such as water. Also disclosed are novel derivatives of 2-ethyl-3-hydroxypyrid-4-one.

  通过将取代的3-羟基吡啶-4-酮与氨或非立体位阻的一级胺反应，通常在水等溶剂的存在下，可以制备取代的3-羟基吡啶-4-酮、其衍生物和盐类。此外，还披露了2-乙基-3-羟基吡啶-4-酮的新衍生物。
• Compositions and methods for chelation therapy
  申请人：Liu Gang

  公开号：US20060030619A1

  公开（公告）日：2006-02-09

  The invention relates to compositions and methods of treatment using an iron chelator, an antioxidant, estrogen, and/or combinations thereof, optionally, linked to a nanoparticle, to treat a subject in need thereof. The compositions and methods may be used to restore or protect the normal functions of osteoblast and osteoclast by depleting iron and inhibiting oxidative damage. The compositions and methods may also be used to increase the bone formation rate in a subject.

  该发明涉及使用铁螯合剂、抗氧化剂、雌激素和/或其组合物的组成物和治疗方法，可选地，与纳米颗粒连接，用于治疗需要的受试者。这些组成物和方法可用于通过耗尽铁元素和抑制氧化损伤来恢复或保护成骨细胞和破骨细胞的正常功能。这些组成物和方法也可用于增加受试者的骨形成速率。
• [EN] PROCESS<br/>[FR] PROCÉDÉ
  申请人：IRON THERAPEUTICS HOLDINGS AG

  公开号：WO2012101442A1

  公开（公告）日：2012-08-02

  The invention provides a method of forming an iron hydroxypyrone compound comprising reacting a hydroxypyrone with a non-carboxylate iron salt in an aqueous solution, and precipitating the iron hydroxypyrone compound from the aqueous solution having a pH of greater than 7.

  本发明提供了一种制备铁羟基吡酮化合物的方法，包括在水溶液中将羟基吡酮与非羧酸铁盐反应，并从pH大于7的水溶液中沉淀出铁羟基吡酮化合物。
• [EN] METHOD OF FORMING IRON HYDROXYPYRONE COMPOUNDS<br/>[FR] METHODE DE FORMATION DE COMPOSES D'HYDROXYPYRONE DE FER
  申请人：VITRA PHARMACEUTICALS LTD

  公开号：WO2003097627A1

  公开（公告）日：2003-11-27

  A method of forming an iron hydroxypyrone compound comprising reacting an iron salt of a carboxylic acid and a hydroxypyrone in an aqueous solution at a pH greater than 7.

  一种形成铁羟基吡酮化合物的方法，包括在pH大于7的水溶液中反应羧酸铁盐和羟基吡酮。
• COMPOSITIONS AND METHODS FOR CHELATION THERAPY
  申请人：Liu Gang

  公开号：US20100310460A1

  公开（公告）日：2010-12-09

  The invention relates to compositions and methods of treatment using an iron chelator, an antioxidant, estrogen, and/or combinations thereof, optionally, linked to a nanoparticle, to treat a subject in need thereof. The compositions and methods may be used to restore or protect the normal functions of osteoblast and osteoclast by depleting iron and inhibiting oxidative damage. The compositions and methods may also be used to increase the bone formation rate in a subject.

  本发明涉及使用铁螯合剂、抗氧化剂、雌激素和/或其组合物，可选地与纳米粒子连接，用于治疗需要的受体的组成物和方法。这些组成物和方法可以通过耗尽铁和抑制氧化损伤来恢复或保护成骨细胞和破骨细胞的正常功能。这些组成物和方法也可以用于提高受体的骨形成速率。