15α,20ξ-Dihydroxypregna-4,6-dien-3-one 15-Acetat | 53154-96-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 15α,20ξ-Dihydroxypregna-4,6-dien-3-one 15-Acetat
• CAS: 53154-96-4
• 化学式: C₂₃H₃₂O₄
• 分子量: 372.505
• InChiKey: NNSKVCCBSWRACQ-KHJSNHEMSA-N

反应信息

• 作为反应物：
  描述：

  15α,20ξ-Dihydroxypregna-4,6-dien-3-one 15-Acetat 在 chromium(VI) oxide 、 硫酸 、 sodium carbonate 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 甲醇 、 二甲基亚砜 、 丙酮 、 苯 为溶剂， 生成 15-Keto-6β,7β-methylen-1-dehydroprogesteron
  参考文献：
  名称：

  Synthesis of 15-keto-6.beta.,7.beta.-methyleneprogesterone. Effect of the 6.beta.,7.beta.-methylene group on mineralocorticoid activity

  摘要：

  15-Ketoprogesterone is as active as spironolactone in blocking the mineralocorticoid effect of deoxycorticosterone acetate. This activity is reduced when a methylene group is attached to the 6beta, 7beta position. The title compound was prepared from 15alpha-acetoxy-6-dehydroprogesterone. Methylenation of the delta6 double bond with dimethyloxosulfonium methylide proceeds steroselectively from the beta side of the molecule.

  DOI：

  10.1021/jm00237a011
• 作为产物：
  描述：

  Acetic acid (8R,9S,10R,13S,14S,15S,17S)-17-acetyl-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-15-yl ester 生成 15α,20ξ-Dihydroxypregna-4,6-dien-3-one 15-Acetat
  参考文献：
  名称：

  Synthesis of 15-keto-6.beta.,7.beta.-methyleneprogesterone. Effect of the 6.beta.,7.beta.-methylene group on mineralocorticoid activity

  摘要：

  15-Ketoprogesterone is as active as spironolactone in blocking the mineralocorticoid effect of deoxycorticosterone acetate. This activity is reduced when a methylene group is attached to the 6beta, 7beta position. The title compound was prepared from 15alpha-acetoxy-6-dehydroprogesterone. Methylenation of the delta6 double bond with dimethyloxosulfonium methylide proceeds steroselectively from the beta side of the molecule.

  DOI：

  10.1021/jm00237a011