Methyl 2-amino-3-(3-chloro-4-hydroxyphenyl)propanoate | 1219411-04-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-amino-3-(3-chloro-4-hydroxyphenyl)propanoate
• CAS: 1219411-04-7
• 化学式: C₁₀H₁₂ClNO₃
• 分子量: 229.66
• InChiKey: KWTIOVPQMRSIJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Method for determination of likelihood of occurrence of preterm labor in pregnant females
  申请人：Woods James

  公开号：US20060166295A1

  公开（公告）日：2006-07-27

  The presence of 3-chlorotyrosine in vaginal secretions in a predictor of the likelihood preterm premature rupture of the fetal membranes, i.e., the chorioamnion and/or the occurrence of the risk of preterm labor. 3-chlorotyrosine is a marker for the excessive production of hypochlorous acid which causes focal areas of increased collagen destruction in the chorioamnion, preterm premature rupture of membranes, or increased production of postaglandin and preterm labor. The inventive method comprises determining the likelihood of the occurrence of preterm premature rupture of membranes or increased production of postaglandin and preterm labor in a pregnant female by obtaining a sample of the females vaginal secretions, and analyzing the secretions for the presence and amount of 3-chlorotyrosine in the sample. Various antibody-based tests can be used to measure 3-chlorotyrosine, and a number of neoantigens, useful in raising antibodies to 3-chlorotyrosine, are disclosed.

  阴道分泌物中 3-氯酪氨酸的存在可预测胎膜（即绒毛膜）早破的可能性和/或发生早产的风险。3-氯酪氨酸是次氯酸过量产生的标志物，次氯酸过量会导致绒毛膜中胶原蛋白破坏的病灶区域增加、胎膜早破或后雌激素的产生增加和早产。本发明的方法包括通过获取女性阴道分泌物样本，并分析样本中 3-氯酪氨酸的存在和含量，来确定怀孕女性发生胎膜早破或后置腺素分泌增加和早产的可能性。各种基于抗体的测试可用于测量 3-氯酪氨酸，已公开的一些新抗原可用于提高 3-氯酪氨酸抗体。
• METHOD FOR DETERMINATION OF LIKELIHOOD OF OCCURRENCE OF PRETERM LABOR IN PREGNANT FEMALES
  申请人：The University of Rochester Medical Center

  公开号：EP1540341A1

  公开（公告）日：2005-06-15
• EP1540341A4
  申请人：——

  公开号：EP1540341A4

  公开（公告）日：2007-01-10
• TYROSINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM
  申请人：Tyme, Inc.

  公开号：EP3060200B1

  公开（公告）日：2021-05-26
• [EN] METHOD FOR DETERMINATION OF LIKELIHOOD OF OCCURRENCE OF PRETERM LABOR IN PREGNANT FEMALES<br/>[FR] METHODE DE DETERMINATION DE LA PROBABILITE DE RISQUE D'ACCOUCHEMENT PREMATURE CHEZ LA FEMME ENCEINTE
  申请人：UNIV ROCHESTER MEDICAL CT

  公开号：WO2004003555A1

  公开（公告）日：2004-01-08

  The presence of 3-chlorotyrosine in vaginal secretions in a predictor of the likelihood preterm premature rupture of the fetal membranes, i.e., the chorioamnion and/or the occurrence of the risk of preterm labor. 3-chlorotyrosine is a marker for the excessive production of hypochlorous acid which causes focal areas of increased collagen destruction in the chorioamnion, preterm premature rupture of membranes, or increased production of postaglandin and preterm labor. The inventive method comprises determining the likelihood of the occurrence of preterm premature rupture of membranes or increased production of postaglandin and preterm labor in a pregnant female by obtaining a sample of the females vaginal secretions, and analyzing the secretions for the presence and amount of 3-chlorotyrosine in the sample. Various antibody-based tests can be used to measure 3-chlorotyrosine, and a number of neoantigens, useful in raising antibodies to 3-chlorotyrosine, are disclosed.