乙二胺-N,N'-二丙酸二盐酸盐 | 32705-91-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 乙二胺-N,N'-二丙酸二盐酸盐
• 中文别名: 分散染料常压沸染聚酯切片；乙二胺-N,N-二丙酸二盐酸盐
• 英文名称: Ethylenediamine-N,N'-dipropionic acid dihydrochloride
• 英文别名: 3-[2-(2-carboxyethylamino)ethylamino]propanoic acid;dihydrochloride
• CAS: 32705-91-2
• 化学式: C8H18Cl2N2O4
• 分子量: 277.14
• InChiKey: GSRDLTQJRCGIQI-UHFFFAOYSA-N

物化性质

• 熔点：
  198 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  98.7
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• [EN] ENGINEERED ANTIMICROBIAL AMPHIPHILIC PEPTIDES AND METHODS OF USE<br/>[FR] PEPTIDES AMPHIPHILES ANTIMICROBIENS MODIFIÉS ET PROCÉDÉS D'UTILISATION
  申请人：PEPTILOGICS INC

  公开号：WO2018160997A1

  公开（公告）日：2018-09-07

  Disclosed herein are novel peptides that can comprise antimicrobial, antiviral, antifungal or antitumor activity when administered to a subject.

  本文披露了一种新型肽，当向受试者施用时，可以具有抗菌、抗病毒、抗真菌或抗肿瘤活性。
• NITROGEN-BASED LINKERS FOR ATTACHING MODIFYING GROUPS TO POLYPEPTIDES AND OTHER MACROMOLECULES
  申请人：Holmes Christopher P.

  公开号：US20090048147A1

  公开（公告）日：2009-02-19

  The present invention relates to a compound comprising a peptide moiety, a linker moiety and a water-soluble polymer moiety such as a poly(ethylene glycol) moiety. The linker moiety is between the peptide moiety and the water-soluble polymer moiety. In certain embodiments, the linker moiety has the structure: wherein α, β, and γ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein κ, ρ, and τ are each integers whose values are independently selected. In other embodiments the linker moiety has the following structure: wherein χ, φ, γ, and η are each integers whose values are independently selected. Alternatively, the linker structure may have the following structure: wherein λ and μ are each integers whose values are independently selected.

  本发明涉及一种化合物，包括肽基团、连接基团和水溶性聚合物基团，例如聚乙二醇基团。连接基团位于肽基团和水溶性聚合物基团之间。在某些实施例中，连接基团具有以下结构：其中α、β和γ分别是独立选择的整数。在其他实施例中，连接基团具有以下结构：其中κ、ρ和τ分别是独立选择的整数。在其他实施例中，连接基团具有以下结构：其中χ、φ、γ和η分别是独立选择的整数。或者，连接结构也可以具有以下结构：其中λ和μ分别是独立选择的整数。
• [EN] ANTI-TM4SF1 ANTIBODY DRUG CONJUGATES AND METHODS OF USING SAME<br/>[FR] CONJUGUÉS ANTICORPS ANTI-TM4SF-MÉDICAMENT ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ANGIEX INC

  公开号：WO2021222783A1

  公开（公告）日：2021-11-04

  Antibody-drug conjugates (ADCs) are described, comprising anti-TM4SF1 antibodies, antigen-binding fragments thereof, a linker and a drug. Methods of use of said ADCs are also describe.

  抗体药物偶联物（ADCs）被描述为包括抗TM4SF1抗体、其抗原结合片段、连接剂和药物。还描述了使用这些ADCs的方法。
• USE OF CHELATORS OF DIVALENT CATIONS TO PROMOTE NERVE REGENERATION
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20140179741A1

  公开（公告）日：2014-06-26

  Disclosed herein are methods to promote axonal outgrowth of a neuron comprising, contacting the neuron with an effective amount of a chelating agent, to thereby promote axonal outgrowth in the neuron. Also disclosed are methods of treating a subject for a CNS lesion, comprising, administering to the subject a therapeutically effective amount of a chelating agent, Also disclosed are devices for promoting regeneration in a lesioned neuron, and pharmaceutical compositions comprising a therapeutically effective amount of a chelating agent formulated for localized administration directly to an injured neuron. Examples of such chelating agents are provided.

  本文揭示了一种促进神经元轴突生长的方法，包括将有效量的螯合剂与神经元接触，从而促进神经元的轴突生长。还揭示了治疗中枢神经系统损伤的方法，包括向受试者施用治疗有效量的螯合剂。还揭示了促进受损神经元再生的装置和制剂，其中包括经局部给药制备的治疗有效量的螯合剂。提供了这种螯合剂的示例。
• Novel, iron complex, process for producing the same, photographic processing composition and processing process using the same
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0713139A1

  公开（公告）日：1996-05-22

  An additive for photography represented by formula (I): wherein R₁ is an aliphatic hydrocarbon group, an aryl group, or a heterocyclic ring group; R₂ is hydrogen, an aliphatic hydrocarbon group, an aryl group, or a heterocyclic ring group; L₁, L₂, L₃, L₄ and L₅ are independently an alkylene group; m and n are independently 0 or 1; W¹ and W² are independently an alkylene group, an arylene group, aralkylene group or a divalent nitrogen-containing heterocyclic ring group; D is a single bond, -O-, -S- or -N(Rw)-, where Rw is hydrogen, an aliphatic hydrocarbon group or an aryl group; v is 0 or an integer of from 1 to 3; w is an integer of from 1 to 3; and M₁, M₂, M₃ and M₄ are independently hydrogen or a cation, photographic processing composition and a processing process using the same.

  一种由式（I）表示的摄影添加剂： 其中 R₁ 是脂肪烃基、芳基或杂环基；R₂ 是氢、脂肪烃基、芳基或杂环基；L₁、L₂、L₃、L₄ 和 L₅ 独立为亚烷基；m 和 n 独立为 0 或 1；W¹ 和 W² 独立为亚烷基、芳烯基、芳烷基或二价含氮杂环基团；D是单键、-O-、-S-或-N(Rw)-，其中Rw是氢、脂肪族烃基或芳基；v是0或1至3的整数；w是1至3的整数；以及M₁、M₂、M₃和M₄独立地是氢或阳离子。

表征谱图