2-Chloro-1-(2-ethylmorpholin-4-yl)ethan-1-one | 1156825-66-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-Chloro-1-(2-ethylmorpholin-4-yl)ethan-1-one
• 英文别名: 2-chloro-1-(2-ethylmorpholin-4-yl)ethanone
• CAS: 1156825-66-9
• 化学式: C₈H₁₄ClNO₂
• mdl: MFCD12139232
• 分子量: 191.65
• InChiKey: QRXDPRNAEJRKPQ-UHFFFAOYSA-N

物化性质

• 沸点：
  309.2±37.0 °C(Predicted)
• 密度：
  1.135±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Benzimidazole derivatives and their uses
  申请人：TEIJIN PHARMA LIMITED

  公开号：US11332459B2

  公开（公告）日：2022-05-17

  The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

  本发明涉及瞬时受体电位通道 6（TRPC6）蛋白活性的抑制剂。本发明提供了式(I)化合物或其药学上可接受的盐、包含本发明化合物的药物组合物、制造本发明化合物的方法及其治疗用途。
• BENZIMIDAZOLE DERIVATIVES AND THEIR USES
  申请人：Amgen Inc.

  公开号：US20200308145A1

  公开（公告）日：2020-10-01

  The present invention relates to inhibitors of Transient Receptor Potential Channel 6 (TRPC6) protein activity. The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.