<1R-(1α,2β,3α,4β,5β)>-5-<(butylaminothiocarbomyl)amino>-1-(tert-butyldimethylsilyloxymethyl)-2,3,4-tris(tert-butyldimethylsilyloxy)cyclopentan-1-ol | 219717-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: <1R-(1α,2β,3α,4β,5β)>-5-<(butylaminothiocarbomyl)amino>-1-(tert-butyldimethylsilyloxymethyl)-2,3,4-tris(tert-butyldimethylsilyloxy)cyclopentan-1-ol
• 英文别名: 1-butyl-3-[(1R,2R,3S,4R,5S)-3,4,5-tris[[tert-butyl(dimethyl)silyl]oxy]-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-2-hydroxycyclopentyl]thiourea
• CAS: 219717-68-7
• 化学式: C₃₅H₇₈N₂O₅SSi₄
• 分子量: 751.423
• InChiKey: YKNQMVHCFUEHEY-XSCXWOQHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.56
• 重原子数：
  47.0
• 可旋转键数：
  13.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  81.21
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  <1R-(1α,2β,3α,4β,5β)>-5-<(butylaminothiocarbomyl)amino>-1-(tert-butyldimethylsilyloxymethyl)-2,3,4-tris(tert-butyldimethylsilyloxy)cyclopentan-1-ol 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 4.0h， 生成 <1R-(1α,2β,3α,4β,5β)>-5-<(butylaminothiocarbomyl)amino>-1-hydroxymethylcyclopentan-1,2,3,4-tetraol
  参考文献：
  名称：

  Syntheses of 1-deoxynojirimycin-trehalamine-fused and -linked compounds and their biological activities

  摘要：

  1-Deoxynojirimycin-trehalamine-fused and -linked compounds (10, 19a and 19b) were synthesized from 1-deoxy-2,3,4,6-tetra-O-benzylnojirimycin and trehazolamine, which was obtained from natural trehazorin as a degradation product. None of these synthetic compounds exceeded 1-deoxynojirimycin in the inhibitory activities towards rat intestinal maltase and yeast alpha-D-glucosidase. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00966-1
• 作为产物：
  描述：

  benzyl N-[(1R,2R,3S,4R,5S)-3,4,5-tris[[tert-butyl(dimethyl)silyl]oxy]-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-2-hydroxycyclopentyl]carbamate 在 palladium on activated charcoal 氢气 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 生成 <1R-(1α,2β,3α,4β,5β)>-5-<(butylaminothiocarbomyl)amino>-1-(tert-butyldimethylsilyloxymethyl)-2,3,4-tris(tert-butyldimethylsilyloxy)cyclopentan-1-ol
  参考文献：
  名称：

  Syntheses of 1-deoxynojirimycin-trehalamine-fused and -linked compounds and their biological activities

  摘要：

  1-Deoxynojirimycin-trehalamine-fused and -linked compounds (10, 19a and 19b) were synthesized from 1-deoxy-2,3,4,6-tetra-O-benzylnojirimycin and trehazolamine, which was obtained from natural trehazorin as a degradation product. None of these synthetic compounds exceeded 1-deoxynojirimycin in the inhibitory activities towards rat intestinal maltase and yeast alpha-D-glucosidase. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00966-1