7-bromo-1-phenylquinoxalin-2(1H)-one | 1201845-33-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-bromo-1-phenylquinoxalin-2(1H)-one
• 英文别名: 7-bromo-1-phenylquinoxalin-2-one
• CAS: 1201845-33-1
• 化学式: C₁₄H₉BrN₂O
• 分子量: 301.142
• InChiKey: BOELYTMMBBZTPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-bromo-1-phenylquinoxalin-2(1H)-one 、 N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)2-methoxy-N-methylethanaminosulfonamide 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride sodium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.33h， 生成 N-(2-chloro-5-(3-oxo-4-phenyl-3,4-dihydroquinoxalin-6-yl)pyridin-3-yl)2-methoxy-N-methylethanaminosulfonamide
  参考文献：
  名称：

  [EN] INHIBITORS OF PI3 KINASE
  [FR] INHIBITEURS DE LA PI3 KINASE

  摘要：

  公开号：

  WO2009155121A3
• 作为产物：
  描述：

  苯硼酸 、 7-溴-2(1H)-喹喔啉酮 在 copper diacetate 氧气 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 7-bromo-1-phenylquinoxalin-2(1H)-one
  参考文献：
  名称：

  [EN] INHIBITORS OF PI3 KINASE
  [FR] INHIBITEURS DE LA PI3 KINASE

  摘要：

  公开号：

  WO2009155121A3

文献信息

• INHIBITORS OF PI3 KINASE
  申请人：Bo Yunxin Y.

  公开号：US20110092504A1

  公开（公告）日：2011-04-21

  The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X 1 , X 2 , R 1 and Z are as defined herein.

  本发明涉及式（I）的化合物，或其药学上可接受的盐；使用该化合物治疗疾病或病症的方法，例如癌症；以及含有该化合物的制药组合物，其中Q、X1、X2、R1和Z的定义如本文所述。
• Inhibitors of PI3 kinase
  申请人：Bo Yunxin Y.

  公开号：US08415376B2

  公开（公告）日：2013-04-09

  The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.

  本发明涉及公式（I）的化合物或其药学上可接受的盐；使用这些化合物治疗癌症等疾病或病况的方法；以及含有这些化合物的制药组合物，其中Q、X1、X2、R1和Z的定义如本文所述。
• Concise SAR Exploration Based on the “Head-to-Tail” Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds
  作者：Satoru Noji、Noriyoshi Seki、Takaki Maeba、Takayuki Sakai、Eiichi Watanabe、Katsuya Maeda、Kyoko Fukushima、Toru Noguchi、Kazuya Ogawa、Yukiyo Toyonaga、Tamotsu Negoro、Hisashi Kawasaki、Makoto Shiozaki

  DOI：10.1021/acsmedchemlett.6b00232

  日期：2016.10.13

  In typical kinase inhibitor programs, a hinge binder showing best potency with preferential specificity is initially selected, followed by fine-tuning of the accompanying substituents on its core module. A shortcoming of this approach is that the exclusive focus on a single chemotype can endanger all the analogues in the series if a critical shortcoming is revealed. Thus, an early evaluation of structure activity relationships (SARs) can mitigate unforeseen outcomes within a series of multiple compounds, although there have been very few examples to follow such a policy. PI4KIII alpha is one of four mammalian phosphatidylinositol-4 kinases and has recently drawn significant attention as an emerging target for hepatitis C virus (HCV) treatment. In this letter, a novel "head-to-tail" approach to discover a diverse set of PI4KIII alpha inhibitors is reported. We believe this method will generate distinct core scaffolds, a rational strategy to circumvent potential risks in general kinase programs.
• US8415376B2
  申请人：——

  公开号：US8415376B2

  公开（公告）日：2013-04-09
• [EN] INHIBITORS OF PI3 KINASE<br/>[FR] INHIBITEURS DE LA PI3 KINASE
  申请人：AMGEN INC

  公开号：WO2009155121A3

  公开（公告）日：2010-02-18