(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-4-methylpentanamide hydrochloride | 1335122-82-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-4-methylpentanamide hydrochloride
• CAS: 1335122-82-1
• 化学式: C₁₅H₂₄N₄O₄*ClH
• 分子量: 360.841
• InChiKey: QBKNHYWKBYRGJP-JKBZPBJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.87
• 重原子数：
  24.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  144.51
• 氢给体数：
  4.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  tert-butyl ((1S,2S)-3-((S)-2-((tert-butoxycarbonyl)amino)-4-methylpentanamido)-1-hydroxy-1-(4-nitrophenyl)propan-2-yl)carbamate 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 反应 4.0h， 以95%的产率得到(S)-2-amino-N-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propyl)-4-methylpentanamide hydrochloride
  参考文献：
  名称：

  Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine

  摘要：

  Aminopeptidase N (APN) is involved in different physiological and pathological processes of tumor cells, including proliferation, invasion, apoptosis and metastasis. Herein one series of compounds derived from commercially available (1S, 2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed and synthesized. Furthermore, preliminary activity evaluation showed that some compounds elicited moderate inhibitory activity against APN with compounds 10e (IC50 = 6.1 +/- 0.5 mu M) possessing the best efficacy, which could be used as the lead compound in the future for anticancer agents research. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.07.008