4-iodo-6-(thiophen-2-yl)pyrimidine | 1279017-38-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-iodo-6-(thiophen-2-yl)pyrimidine
• 英文别名: 4-Iodo-6-thiophen-2-yl-pyrimidine；4-iodo-6-thiophen-2-ylpyrimidine
• CAS: 1279017-38-7
• 化学式: C₈H₅IN₂S
• 分子量: 288.112
• InChiKey: TWLJPJMAZQFIDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-6-(thien-2'-yl)pyrimidine 在 氢碘酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 20.0h， 以94.1%的产率得到4-iodo-6-(thiophen-2-yl)pyrimidine
  参考文献：
  名称：

  [EN] NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS
  [FR] NOUVEAUX DÉRIVÉS D'IODO PYRIMIDINES UTILES POUR LE TRAITEMENT DE MALADIES OU AFFECTIONS LIÉES AU FACTEUR INHIBITEUR DE LA MIGRATION DES MACROPHAGES

  摘要：

  公开号：

  WO2011038234A3

文献信息

• NOVEL IODO PYRIMIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS
  申请人：Mitchell Robert A.

  公开号：US20130079361A1

  公开（公告）日：2013-03-28

  Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.

  本文提供了用于抑制巨噬细胞迁移抑制因子（MIF）的化合物，其化学式为（I）：其中A选自芳香环、非芳香环、双环、多环、烯烃或炔烃；B为H、OH、OR、SR、NH2、NHR或烷基；R为H或烷基，X和Y独立地为N或CH，但其中一个必须为N。此外，还提供了包含I式化合物的药物组合物和治疗MIF相关疾病或病情的方法，包括给予I式化合物的安全有效剂量。
• Iodo pyrimidine derivatives useful for the treatment of macrophage migration inhibitory factor (MIF)-implicated diseases and conditions
  申请人：Mitchell Robert A.

  公开号：US09162987B2

  公开（公告）日：2015-10-20

  Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula (I): wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH2, NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions comprising a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions, comprising administering a safe and effective amount of a Formula I compound.

  本文提供了用于抑制巨噬细胞迁移抑制因子（MIF）的化合物，其具有以下式子（I）：其中A选自芳香环、非芳香环、双环、多环、烯烃或炔烃组成的群体；B为H、OH、OR、SR、NH2、NHR或烷基；R为H或烷基，X和Y独立地为N或CH，但其中一个必须为N。还提供了包含式I化合物的制药组合物和治疗MIF相关疾病或病症的方法，包括给予安全有效的式I化合物量。
• METHOD FOR TREATING MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)-IMPLICATED DISEASES AND CONDITIONS WITH IODO PYRIMIDINE DERIVATIVES
  申请人：UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

  公开号：US20150368207A1

  公开（公告）日：2015-12-24

  Compounds useful for the inhibition of macrophage migration inhibitory factor (MIF) are provided herein, having the Formula I: wherein A is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; B is H, OH, OR, SR, NH 2 , NHR, or alkyl; R is H or alkyl, and X and Y are independently N or CH, but one of X and Y must be N. Also provided are pharmaceutical compositions that contain a Formula I compound and methods for the treatment of MIF-implicated diseases or conditions that include administering a safe and effective amount of a Formula I compound.

  本文提供了用于抑制巨噬细胞迁移抑制因子（MIF）的化合物，其具有公式I：其中A选择自芳香环或非芳香环、双环环、多环环、烯烃或炔烃的群体；B是H、OH、OR、SR、NH2、NHR或烷基；R是H或烷基，而X和Y独立地是N或CH，但其中一个必须是N。还提供了含有公式I化合物的药物组合物，以及治疗涉及MIF的疾病或病状的方法，包括给予安全有效量的公式I化合物。
• METHODS AND COMPOSITIONS FOR MODULATING OCULAR DAMAGE
  申请人：Tezel Tongalp H.

  公开号：US20130177552A1

  公开（公告）日：2013-07-11

  Methods for modulating eye damage associated with a disease or disorder, and/or damage incident to trauma including but not limited to trauma associated with ocular surgery are provided. In some embodiments, the methods include administering an effective amount of a modulator of a migration inhibitory factor (MIF) polypeptide biological activity to a subject. Also provided are methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of an ocular disease, and methods for modulating the severity of delaying the onset of and/or inhibiting and/or preventing the development of scarring and/or other consequence of wound healing incident to ocular surgery, as well as modulating the survival, function, and/or differentiation of engrafted cells that can be employed as part of tissue engineering procedures to correct structural, functional, and/or cellular defects of the eye.
• US9162987B2
  申请人：——

  公开号：US9162987B2

  公开（公告）日：2015-10-20