β-Chlorhexafluorisopropylacrylat | 13057-09-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: β-Chlorhexafluorisopropylacrylat
• 英文别名: Acrylic acid 1-(chlorodifluoromethyl)-1,2,2,2-tetrafluoroethyl ester；(1-chloro-1,1,2,3,3,3-hexafluoropropan-2-yl) prop-2-enoate
• CAS: 13057-09-5
• 化学式: C₆H₃ClF₆O₂
• 分子量: 256.532
• InChiKey: DEVOUEDEOXKVPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Stent with differential timing of abluminal and luminal release of a therapeutic agent
  申请人：Boston Scientific Limited

  公开号：EP2305323A2

  公开（公告）日：2011-04-06

  A stent designed for implantation into a blood vessel of a patient comprising: a tubular stent sidewall structure comprising a plurality of struts and openings in the sidewall structure; wherein at least one strut comprises an abluminal surface, a luminal surface opposite the abluminal surface, and side surfaces extending between the luminal and abluminal surfaces; a first coating composition disposed on the abluminal surface and luminal surface; and a second coating composition disposed on a portion of the first coating composition; characterized in that the portion is disposed either only on the abluminal surface and side surfaces or only on the abluminal surface; and when the stent is implanted, the second coating composition disposed on the abluminal surface faces the blood vessel.

  一种用于植入患者血管的支架，包括 管状支架侧壁结构，包括多个支杆和侧壁结构中的开口；其中至少一个支杆包括一个管腔表面、一个与管腔表面相对的管腔表面以及在管腔表面和管腔表面之间延伸的侧表面； 设置在腔体表面和腔体表面上的第一涂层组合物； 以及 第二涂层组合物，置于第一涂层组合物的一部分上；其特征在于 该部分 仅设置在腔体表面和侧表面上，或 仅设置在腔内表面；以及 当植入支架时，设置在消融面上的第二涂层组合物面向血管。
• Medical device for delivering biologically active material
  申请人：——

  公开号：US20030144727A1

  公开（公告）日：2003-07-31

  A medical device for delivering a biologically active material into a body tissue, comprising struts and optionally the biologically active material. In an embodiment, the medical device comprises non-structural elements integral with the struts. A method for designing such medical device are also disclosed. Another embodiment is a medical device having an outer surface comprising a middle section and end sections. The end sections have a greater available surface area, greater affinity for or a greater amount of the biologically active material per unit length of the outer surface than the middle section. The middle section may be covered with a barrier layer. Another embodiment is a medical device comprising a rectangular portion having a greater capacity for carrying a biologically active material per unit length of the outer surface. A method for delivering a biologically active material to a body tissue is also disclosed.

  一种用于向人体组织输送生物活性材料的医疗设备，包括支杆和生物活性材料。在一个实施方案中，该医疗器械包括与支杆一体的非结构元件。此外，还公开了设计此类医疗设备的方法。另一个实施方案是一种医疗设备，其外表面包括中间部分和端部。与中间部分相比，末端部分的可用表面积更大，与生物活性材料的亲和力更强，或外表面单位长度上的生物活性材料量更大。中间部分可覆盖隔离层。另一个实施方案是一种医疗器械，包括矩形部分，其外表面每单位长度具有更大的生物活性材料承载能力。还公开了一种向身体组织输送生物活性材料的方法。
• Layered silicate nanoparticles for controlled delivery of therapeutic agents from medical articles
  申请人：Zhong Sheng-Ping (Samuel)

  公开号：US20050181015A1

  公开（公告）日：2005-08-18

  Medical articles (for instance, a drug delivery patch or an implantable or insertable medical device) are provided that comprise a release region, which in turn comprises (a) polymeric carrier comprising a polymer (for instance, a hydrophobic polymer) and (b) drug loaded nanoparticles, which are dispersed within the polymeric carrier. The drug loaded nanoparticles comprise a layered silicate material (for instance synthetic or naturally occurring smectite clay nanoparticles) and a therapeutic agent (for instance, a hydrophilic or hydrophobic therapeutic agent). Also described are methods of releasing a therapeutic agent to a patient using such medical articles, and methods of making such medical articles.

  医疗用品（例如，给药贴片或植入式或插入式医疗设备）包括释放区域，释放区域又包括（a）由聚合物（例如，疏水性聚合物）组成的聚合物载体和（b）分散在聚合物载体中的载药纳米颗粒。装载药物的纳米颗粒包括层状硅酸盐材料（例如合成的或天然存在的smectite粘土纳米颗粒）和治疗剂（例如亲水性或疏水性治疗剂）。还描述了使用此类医疗用品向患者释放治疗剂的方法，以及制造此类医疗用品的方法。
• Stent for delivering a therapeutic agent having increased body tissue contact surface
  申请人：Flanagan Aiden

  公开号：US20060095123A1

  公开（公告）日：2006-05-04

  A stent for implantation in a body lumen is described comprising at least one strut having an inner surface, an outer surface, a first side surface disposed between the inner surface and the outer surface, and a second side surface disposed between the inner surface and the outer surface; wherein the first side surface and the second side surface converge toward one another in the direction of the outer surface; and a coating comprising a therapeutic agent disposed on at least a portion of a surface of the strut.

  描述了一种用于植入体内管腔的支架，包括至少一个支杆，该支杆具有一个内表面、一个外表面、一个位于内表面和外表面之间的第一侧表面，以及一个位于内表面和外表面之间的第二侧表面；其中，第一侧表面和第二侧表面在外侧表面的方向上相互汇聚；以及一个涂层，该涂层包括一个设置在支杆表面至少一部分上的治疗剂。
• SAMPLE HOLDER WITH HYDROPHOBIC COATING FOR GAS PHASE MASS SPECTROMETERS
  申请人：Ciphergen Biosystems, Inc.

  公开号：EP1181705A2

  公开（公告）日：2002-02-27