Methyl 3-[2-aminoethyl-(3-methoxy-3-oxopropyl)amino]propanoate | 870767-16-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 3-[2-aminoethyl-(3-methoxy-3-oxopropyl)amino]propanoate
• CAS: 870767-16-1
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: VSDOKOBBBPITKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  81.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 3-[2-aminoethyl-(3-methoxy-3-oxopropyl)amino]propanoate 、 N-(4-(carbazol-9-yl)-phenyl)-N-maleimide 以 二氯甲烷 为溶剂， 以0.25 g的产率得到
  参考文献：
  名称：

  来自水中咔唑基染料的深蓝色发光纳米聚集体

  摘要：

  透射电子显微镜和原子力显微镜观察到，新型两亲咔唑染料在水中组装成深蓝色发光、高荧光的螺旋聚集体。单晶 X 射线衍射和核磁共振谱表明，自互补、反平行的氢键和 π-π 堆积相互作用是形成这些染料聚集体的驱动力。

  DOI：

  10.1039/d1cc05441d
• 作为产物：
  描述：

  dimethyl 3,3'-((2-((tert-butoxycarbonyl)amino)ethyl)azanediyl)dipropionate 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.17h， 生成 Methyl 3-[2-aminoethyl-(3-methoxy-3-oxopropyl)amino]propanoate
  参考文献：
  名称：

  来自水中咔唑基染料的深蓝色发光纳米聚集体

  摘要：

  透射电子显微镜和原子力显微镜观察到，新型两亲咔唑染料在水中组装成深蓝色发光、高荧光的螺旋聚集体。单晶 X 射线衍射和核磁共振谱表明，自互补、反平行的氢键和 π-π 堆积相互作用是形成这些染料聚集体的驱动力。

  DOI：

  10.1039/d1cc05441d

文献信息

• Amine-containing lipids and uses thereof
  申请人：Anderson Daniel G.

  公开号：US20110009641A1

  公开（公告）日：2011-01-13

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• AMINE-CONTAINING LIPIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160009657A1

  公开（公告）日：2016-01-14

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
• COMPOSITIONS AND METHODS FOR THE DELIVERY OF NUCLEIC ACIDS
  申请人：CASE WESTERN RESERVE UNIVERSITY

  公开号：US20160145610A1

  公开（公告）日：2016-05-26

  A compound comprising formula (I): wherein R 1 is an akylamino group or a group containing at least one aromatic group; R 2 and R 3 are independently an aliphatic group or hydrophobic group; R 4 and R 5 are independently H, a substituted or unsubstituted akyl group, an akenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety; a, b, c, and d are independently an integer from 1 to 10; and pharmaceutically acceptable salts thereof.
• US9006487B2
  申请人：——

  公开号：US9006487B2

  公开（公告）日：2015-04-14