tetramethyl-succinic acid diamide | 32907-03-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tetramethyl-succinic acid diamide
• 英文别名: tetramethylsuccinamide；2,2,3,3-Tetramethylbutanediamide
• CAS: 32907-03-2
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.227
• InChiKey: IBTDKHGMMTZMJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• COMPOUNDS AND SYNTHETIC METHODS FOR THE PREPARATION OF RETINOID X RECEPTOR-SPECIFIC RETINOIDS
  申请人：Io Therapeutics, Inc.

  公开号：US20200190008A1

  公开（公告）日：2020-06-18

  Provided herein are compounds useful for the preparation of compounds that have retinoid-like biological activity. Also provided herein are processes for the preparation of compounds that have retinoid-like biological activity.

  本文提供了用于制备具有类视黄醇生物活性化合物的化合物。本文还提供了制备具有类视黄醇生物活性化合物的过程。
• [EN] ANTIBACTERIAL AGENTS<br/>[FR] AGENTS ANTIBACTERIENS
  申请人：BRITISH BIOTECH PHARM

  公开号：WO1999039704A1

  公开（公告）日：1999-08-12

  Compounds of formula (I) are antibacterials: wherein R1 represents hydrogen, or C1-C6 alkyl or C1-C6 alkyl substituted by one or more halogen atoms; R2 represents a group R10-(X)n-(ALK)M- wherein R10 represents hydrogen, or a C1-C6 alkyl, C2-C6 alkenyl,C2-C6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C1-C6) alkyl, (C1-C6) alkoxy, hydroxy, mercapto, (C1-C6) alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, -COOH, -CONH2, -COORA, -NHCORA, -CONHR?A, -NHRA, -NRARB¿, or -CONRARB wherein R?A and RB¿ are independently a (C¿1?-C6) alkyl group, and ALK represents a straight or branched divalent C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene radical, and may be interrupted by one or more non-adjacent -NH-, -O- or -S- linkages, X represents -NH-, -O- or -S-, and m and n are independently 0 or 1; and A represents a group as defined in the specification.

  式(I)的化合物为抗菌剂，其中R1代表氢，或C1-C6烷基或C1-C6烷基取代的一个或多个卤素原子；R2代表一个基团R10-(X)n-(ALK)M-，其中R10代表氢，或C1-C6烷基，C2-C6烯基，C2-C6炔基，环烷基，芳基或杂环基，任何一个都可以是未取代或取代的(C1-C6)烷基，(C1-C6)烷氧基，羟基，巯基，(C1-C6)烷硫基，氨基，卤素（包括氟，氯，溴和碘），三氟甲基，氰基，硝基，-COOH，-CONH2，-COORA，-NHCORA，-CONHR?A，-NHRA，-NRARB¿，或者 -CONRARB，其中R?A和RB¿独立地为(C¿1?-C6)烷基，ALK代表直链或支链的二价C1-C6亚烷基，C2-C6烯基或C2-C6炔基基团，并且可以被一个或多个不相邻的-NH-，-O-或-S-连接所中断，X代表-NH-，-O-或-S-，m和n独立地为0或1；A代表规范中定义的一个基团。
• Antibacterial agents
  申请人：British Biotech Pharmaceuticals Ltd.

  公开号：US20020165167A1

  公开（公告）日：2002-11-07

  Compounds of formula (I) are antibacterials: 1 wherein: R 1 represents hydrogen, or C 1 -C 6 alkyl or C 1 -C 6 alkyl substituted by one or more halogen atoms; R 2 represents a group R 10 —(X) n —(ALK) m — wherein R 10 represents hydrogen, or a C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, cycloalkyl, aryl, or heterocyclyl group, any of which may be unsubstituted or substituted by (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, hydroxy, mercapto, (C 1 -C 6 )alkylthio, amino, halo (including fluoro, chloro, bromo and iodo), trifluoromethyl, cyano, nitro, —COOH, —CONH 2 , —COOR A , —NHCOR A , —CONH A , —NH A , —NR A R B , or —CONR A R B wherein R A and R B are independently a (C 1 -C 6 )alkyl group, and ALK represents a straight or branched divalent C 1 -C 6 alkylene, C 2 -C 6 alkenylene, or C 2 -C 6 alkynylene radical, and may be interrupted by one or more non-adjacent —NH—, —O— or —S—linkages, X represents —NH—, —O— or —S—, and m and n are independently 0 or 1; and A represents a group as defined in the specification.

  式(I)的化合物是抗菌剂： 其中： R1代表氢，或者C1-C6烷基，或者被一个或多个卤素原子取代的C1-C6烷基； R2代表一个R10-(X)n-(ALK)m-基团，其中R10代表氢，或者C1-C6烷基，C2-C6烯基，C2-C6炔基，环烷基，芳基，或者杂环烷基，任何一个基团可以是未取代的或者被(C1-C6)烷基，(C1-C6)烷氧基，羟基，巯基，(C1-C6)烷硫基，氨基，卤素(包括氟，氯，溴和碘)，三氟甲基，氰基，硝基，-COOH，-CONH2，-COORA，-NHCORA，-CONHA，-NHA，-NRARB，或者-CONRARB取代的，其中RA和RB独立地表示(C1-C6)烷基，ALK表示直链或支链的双价C1-C6烷基，C2-C6烯基或C2-C6炔基基团，并且可以被一个或多个非相邻的-NH-，-O-或-S-键中断，X表示-NH-，-O-或-S-，m和n独立地表示0或1；A表示规范中定义的基团。
• Amino acid derivatives of indolinone based protein kinase inhibitors
  申请人：Liang Congxin

  公开号：US20080269212A1

  公开（公告）日：2008-10-30

  Amino acid derivatives of pyrrolyl-indolinones and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  吡咯基吲哚酮的氨基酸衍生物以及它们的酰胺或酯衍生物具有增强和意外的药物特性，作为蛋白激酶抑制剂，对治疗与异常蛋白激酶活性相关的疾病如癌症非常有用。
• AMINO ACID DERIVATIVES OF INDOLINONE BASED PROTEIN KINASE INHIBITORS
  申请人：Liang Congxin

  公开号：US20090068718A1

  公开（公告）日：2009-03-12

  Amino acid derivatives of pyrrolyl-indolinones and their amide or ester derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.

  吡咯基吲哚酮的氨基酸衍生物及其酰胺或酯衍生物具有增强和意外的药物特性，可作为蛋白激酶抑制剂用于治疗与异常蛋白激酶活性相关的疾病，如癌症。