Boc-Tyr(Bzl)-Pro-OH | 78331-30-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Tyr(Bzl)-Pro-OH
• 英文别名: Boc-Tyr(Bn)-Pro-OH；(2S)-1-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylmethoxyphenyl)propanoyl]pyrrolidine-2-carboxylic acid
• CAS: 78331-30-3
• 化学式: C₂₆H₃₂N₂O₆
• 分子量: 468.55
• InChiKey: SSVBICLTMZTRGE-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Boc-Tyr(Bzl)-Pro-OH 以100%的产率得到
  参考文献：
  名称：

  PERSEO, G.;GIGLI, M.;DE, CASTIGLIONE R., INT. J. PEPTIDE AND PROTEIN RES., 29,(1987) N 4, 478-485

  摘要：

  DOI：
• 作为产物：
  描述：

  Boc-O-苄基-L-酪氨酸 在 氢氧化钾 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 1.5h， 生成 Boc-Tyr(Bzl)-Pro-OH
  参考文献：
  名称：

  Schoen, I.; Szirtes, T.; Rill, A., Acta Chimica Hungarica, 1991, vol. 128, # 6, p. 751 - 773

  摘要：

  DOI：

文献信息

• Degradation of Azaglycinamido Residues in Model Tripeptides Derived from Goserelin
  作者：Marnix A. Hoitink、Jos H. Beijnen、Auke Bult、J.Mirjam A. Damen、Oeds A.G.J. van der Houwen、John A.W. Kruijtzer、Matthijs M. Tibben、Gerard Wiese、Willy J.M. Underberg

  DOI：10.1002/(sici)1520-6017(200001)89:1<108::aid-jps11>3.0.co;2-a

  日期：2000.1

  Three model tripeptides, N-acetyl-Tyr-Pro-azaGly-NH2 (NYPaG), Tyr-Pro-azaGly-NH2 (YPaG), and Tyr-Pro-Gly-NH2(YPG), were subjected to a systematic degradation study to get information about the degradation of the azaglycinamido residue. The degradation products were characterized with LC-MS. Main degradation products of NYPaG possess partially or totally eliminated azaglycinamido residues, while YPaG and YPG are exhibit cyclo(Tyr-Pro) formation, a diketopiperazine. The influence of the pH on the degradation rate constant k(obs) was investigated for NYPaG and YPaG in the pH range 0.4-11. An U-shaped profile with an inflexion around pH 9 was found for NYPaG while the degradation rate of YPaG was independent of the pH. NYPaG apparently was subject to proton-, solvent-, and hydroxyl-catalyzed degradation reactions whereas YPaG only underwent solvent-catalyzed reactions. Some influence of acetate and phosphate ions on k(obs) was found fur YPaG. Arrhenius plots of NYPaG and YPaG; were found to be linear. (C) 2000 Wiley-Liss, Inc. and the American Pharmaceutical Association.