(S)-3-((1-adamantyl)methyl)-5-(t-butyl)oxazolidin-2-one | 1050520-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (S)-3-((1-adamantyl)methyl)-5-(t-butyl)oxazolidin-2-one
• 英文别名: (5S)-3-(1-adamantylmethyl)-5-tert-butyl-1,3-oxazolidin-2-one
• CAS: 1050520-62-1
• 化学式: C₁₈H₂₉NO₂
• 分子量: 291.434
• InChiKey: ZGXBQWCTLMTHKT-GNFNDJEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• CYCLIC UREA AND CARBAMATE INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：Claremon David A.

  公开号：US20100197675A1

  公开（公告）日：2010-08-05

  This invention relates to novel compounds of the Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 β-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.

  本发明涉及公式(I)的新化合物，其药物可接受的盐和药物组合物，用于治疗与哺乳动物中11β-HSD1调节或抑制相关的疾病。本发明还涉及新化合物的药物组合物和它们在细胞中降低或控制皮质醇的产生或抑制皮质酮转化为皮质醇的方法。
• CYCLIC UREA AND CARBAMATE INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：Vitae Pharmaceuticals, Inc.

  公开号：EP2125750A2

  公开（公告）日：2009-12-02
• US8835426B2
  申请人：——

  公开号：US8835426B2

  公开（公告）日：2014-09-16
• [EN] CYCLIC UREA AND CARBAMATE INHIBITORS OF 11ß -HYDROXYSTEROID DEHYDROGENASE 1<br/>[FR] INHIBITEURS D'URÉE ET DE CARBAMATE DE 11B-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE 1 CYCLIQUES
  申请人：VITAE PHARMACEUTICALS INC

  公开号：WO2008106128A2

  公开（公告）日：2008-09-04

  [EN] This invention relates to novel compounds of the Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 ß-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
  [FR] L'invention concerne des nouveaux composés de la formule (I), leurs sels pharmaceutiquement acceptables, et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique de maladies associées avec la modulation ou l'inhibition de 11b-HSD1 chez les mammifères. L'invention concerne en outre des compositions pharmaceutiques des nouveaux composés et des procédés pour leur utilisation dans la réduction ou le contrôle de la production de cortisol dans une cellule, ou l'inhibition de la conversion de la cortisone en cortisol dans une cellule.