1,2-desethyl-panaxytriol | 1214276-07-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,2-desethyl-panaxytriol
• 英文别名: (7R,8R)-tetradeca-2,4-diyne-1,7,8-triol；(7R,8R)-pentadeca-2,4-diyne-1,7,8-triol
• CAS: 1214276-07-9
• 化学式: C₁₅H₂₄O₃
• 分子量: 252.354
• InChiKey: YTOCIIZDSJBVOI-HUUCEWRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING TOXICITY AND TREATING OR PREVENTING DISEASES
  申请人：Danishefsky Samuel J.

  公开号：US20110312904A1

  公开（公告）日：2011-12-22

  The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).

  本发明提供了公式(I)的化合物，以及包含公式(I)化合物的有效量的组合物，可选地与化疗药物如微管结合药物一起使用，并用于减少细胞毒性药物的毒性，治疗或预防癌症或神经病理性障碍，诱导化学保护性II期酶、DNA或蛋白质合成，增强免疫系统，治疗炎症，改善和增强整体健康或福祉，以及制备公式(I)化合物的方法。
• US8859615B2
  申请人：——

  公开号：US8859615B2

  公开（公告）日：2014-10-14
• [EN] REDUCTION OF TOXICITIES BY SYNTHETIC PANAXYTRIOL ANALOGS<br/>[FR] DIMINUTION DES TOXICITÉS PAR ANALOGUES DE SYNTHÈSE DU PANAXYTRIOL
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2014113635A1

  公开（公告）日：2014-07-24

  The present invention provides compounds, compositions and methods for promoting the healing of or reducing injury caused by chemical or radiation damage, minimizing deleterious effects on normal cells in cancer therapy, and treating and preventing cancer and micrometastasis. Radiation damage is caused by many radiation sources. In some embodiments, the radiation damage is caused by radiation therapy, such as cancer radiation therapy. In some embodiments, the radiation damage is caused by a nuclear accident, including a nuclear power plant accident. In some other embodiments, radiation damage is caused by, for example but not limited to, nuclear terrorism, nuclear weapons, and natural radiation, such as that from outer space or the earth.