bimatoprost analogue e2 | 1219032-20-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: bimatoprost analogue e2
• 英文别名: 17-phenyl trinor Prostaglandin E2 ethyl amide；(Z)-N-ethyl-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxy-5-phenylpent-1-enyl]-5-oxocyclopentyl]hept-5-enamide
• CAS: 1219032-20-8
• 化学式: C₂₅H₃₅NO₄
• 分子量: 413.557
• InChiKey: XKYMIHJCJJUECW-XYOQMNIYSA-N

物化性质

• 沸点：
  629.4±55.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)
• 溶解度：
  DMF：100mg/mL；二甲基亚砜：100mg/mL；乙醇：100mg/mL； PBS（pH 7.2）：0.5 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  30
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COMPOSITIONS AND METHODS TO TREAT EPITHELIAL-RELATED CONDITIONS
  申请人：Lipkin Pamela

  公开号：US20100074857A1

  公开（公告）日：2010-03-25

  The described invention relates to the formulation and delivery of compositions to treat an epithelial-related condition selected from the group consisting of sparse hair growth, short hair growth, thin hair growth, alopecia and hair depigmentation and methods for their use. In some embodiments, the composition contains a first component and a second component wherein the first component is at least one prostaglandin analog and the second component is at least one imidazole analog, such that the at least one imidazole analog improves the efficacy of the at least one prostaglandin analog when delivered to a subject refractory to the effect of the prostaglandin analog alone.