(4R)-4-[(6-Amino-1-oxohexyl)amino]-1-(phenylsulfonyl)-L-proline | 409325-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R)-4-[(6-Amino-1-oxohexyl)amino]-1-(phenylsulfonyl)-L-proline
• 英文别名: (2S,4R)-4-(6-aminohexanoylamino)-1-(benzenesulfonyl)pyrrolidine-2-carboxylic acid
• CAS: 409325-38-8
• 化学式: C₁₇H₂₅N₃O₅S
• 分子量: 383.5
• InChiKey: XHMJMSDPXQNGJK-HIFRSBDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  138
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists
  申请人：Mundy Gregory R.

  公开号：US20100183599A1

  公开（公告）日：2010-07-22

  Antagonists of α4 integrin/α4 integrin ligand adhesion, which inhibit the biological effects of such adhesion are described and methods for their use are detailed. Such antagonists are useful in suppressing bone destruction associated with multiple myeloma. The homing of multiple myeloma cells to bone marrow and their α4 integrin-dependent release of bone-resorbing factors, resulting in bone destruction in patients with multiple myeloma, is inhibited.
• US7618630B2
  申请人：——

  公开号：US7618630B2

  公开（公告）日：2009-11-17