(+/-)-[(1S,5R,6R)-6-aminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid | 1252822-47-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-[(1S,5R,6R)-6-aminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
• 英文别名: [(1S,5R,6R)-6-aminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid；2-[(1S,5R,6R)-6-(aminomethyl)-3-methyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid
• CAS: 1252822-47-1
• 化学式: C₁₁H₁₇NO₂
• 分子量: 195.261
• InChiKey: HJNICJYALOSZRL-QXEWZRGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  [(1S,5R,6R)-6-tert-butoxycarbonylaminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid benzenesulfonic acid 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以63%的产率得到(+/-)-[(1S,5R,6R)-6-aminomethyl-3-methylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid
  参考文献：
  名称：

  BICYCLIC -AMINO ACID DERIVATIVE

  摘要：

  公开号：

  EP2192109B1

文献信息

• BICYCLIC gamma-AMINO ACID DERIVATIVE
  申请人：SHIMADA KOUSEI

  公开号：US20100249229A1

  公开（公告）日：2010-09-30

  It is intended to provide a bicyclic γ-amino acid derivative having excellent activity as an α 2 δ ligand. The present invention provides a compound represented by the general formula (I): wherein R 1 , R 2 , R 2′ , R 4 , R 5 , R 6 , R 7 , R 8 , and R 8′ are a hydrogen atom or the like; and R 3 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like.

  本发明旨在提供一种具有作为α2δ配体的优异活性的双环γ-氨基酸衍生物。本发明提供一种由通式(I)表示的化合物：其中R1、R2、R2'、R4、R5、R6、R7、R8和R8'是氢原子或类似物；而R3是氢原子、卤素原子、C1-C6烷基或类似物。
• Bicyclic γ-amino acid derivative
  申请人：Daiichi Sankyo Company, Ltd.

  公开号：US07947738B2

  公开（公告）日：2011-05-24

  It is intended to provide a bicyclic γ-amino acid derivative having excellent activity as an α2δ ligand. The present invention provides a compound represented by the general formula (I): wherein R1, R2, R2′, R4, R5, R6, R7, R8, and R8′ are a hydrogen atom or the like; and R3 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group, or the like.

  本发明旨在提供一种具有优异的α2δ配体活性的双环γ-氨基酸衍生物。本发明提供了一种由通式（I）表示的化合物：其中R1、R2、R2'、R4、R5、R6、R7、R8和R8'是氢原子或类似物；而R3是氢原子、卤素原子、C1-C6烷基或类似物。
• Intermediate for producing bicyclic y-amino acid derivative
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2657219A1

  公开（公告）日：2013-10-30

  An intermediate represented by the general formula (1) is provided, useful for producing a bicyclic γ-amino acid derivative having excellent activity as an α2δ ligand: wherein R1, R2, R2', R4, R5, R8 and R8' are each independently a hydrogen atom, and R3 is a hydrogen atom, a methyl group, an ethyl group, a propyl group, or a butyl group.

  本发明提供了通式 (1) 所代表的中间体，可用于生产作为 α2δ 配体具有优异活性的双环 γ 氨基酸衍生物： 其中 R1、R2、R2'、R4、R5、R8 和 R8'各自独立地为氢原子，R3 为氢原子、甲基、乙基、丙基或丁基。
• PRODRUGS OF ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Gallop Mark A.

  公开号：US20110124705A1

  公开（公告）日：2011-05-26

  Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.
• PRODRUGS OF GAMMA-AMINO ACID, ALPHA-2-DELTA LIGANDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Gallop Mark A.

  公开号：US20110130454A1

  公开（公告）日：2011-06-02

  Prodrugs of alpha-2-delta ligands, pharmaceutical compositions of prodrugs of alpha-2-delta ligands, methods of making prodrugs of alpha-2-delta ligands, and methods of using prodrugs of alpha-2-delta ligands and pharmaceutical compositions of prodrugs of alpha-2-delta ligands to treat various diseases are disclosed.