n-pentyl-palmitate | 114161-35-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: n-pentyl-palmitate
• 英文别名: 2-pentyl-hexadecanoic acid；2-Pentyl-hexadecansaeure；2-Pentylhexadecanoic acid
• CAS: 114161-35-2
• 化学式: C₂₁H₄₂O₂
• 分子量: 326.563
• InChiKey: GMPSAVWLDKCDMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  n-pentyl-palmitate 在 4-二甲氨基吡啶 、 氨 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 为溶剂， 生成 rac-1-(2-pentylhexadecanoyl)-2-O-hexadecylphosphoethanolamine
  参考文献：
  名称：

  Structures and phase transitions in aqueous dispersions of branched-chain glycerophosphoethanolamines

  摘要：

  通过改变侧链长度，合成了具有 α-支链脂肪酸的甘油磷乙醇胺。应用差示扫描量热法和 X 射线衍射法研究了化学变化对物理化学参数和在脂水分散体中形成的结构的影响。结果表明，侧链的引入和逐步拉长降低了从凝胶到液晶相的转变温度。Tm值通过一个最小值，并在进入三链脂质时略有上升。转变参数的变化与改变的多态性有关。短侧链会导致凝胶态的倾斜，而分支的拉长则会导致相互咬合的凝胶相。随着侧链长度的增加，非胶束液晶相得到稳定。对于长支链衍生物，提出了相邻双分子层的头基团相互咬合的观点。

  DOI：

  10.1039/b003516p
• 作为产物：
  描述：

  1-溴戊烷 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 n-pentyl-palmitate
  参考文献：
  名称：

  Breusch; Ulusoy, Chemische Berichte, 1953, vol. 86, p. 688,690,691

  摘要：

  DOI：

文献信息

• Shampoo compositions and suspending agent therefor
  申请人：HELENE CURTIS, INC.

  公开号：EP0562639A1

  公开（公告）日：1993-09-29

  A hair shampoo composition comprising a cleansing surfactant; a water-insoluble hair treating compound, like a hair conditioner or an antidandruff agent; a suspending agent comprising an amine including at least one long carbon chain and a suitable acid; and a suitable carrier, and a method of treating hair are disclosed. The shampoo compositions effectively suspend the water-insoluble hair-treating compound, effectively cleanse the hair and effectively deliver the water-insoluble hair-treating compound to the hair or scalp.

  本发明公开了一种洗发水组合物，该组合物包含清洁表面活性剂；水不溶性头发处理化合物，如护发素或去屑剂；悬浮剂，该悬浮剂包含包含至少一条长碳链的胺和一种合适的酸；以及一种合适的载体和一种处理头发的方法。洗发水组合物能有效地悬浮水不溶性头发处理化合物，有效地清洁头发，并有效地将水不溶性头发处理化合物输送到头发或头皮。
• Conditioning shampoo composition and method of preparing and using the same
  申请人：HELENE CURTIS, INC.

  公开号：EP0566049A1

  公开（公告）日：1993-10-20

  A conditioning shampoo composition comprising: (a) an anionic cleansing surfactant, such as an alkyl ether sulfate or an alkyl sulfate, like sodium lauryl ether sulfate or ammonium lauryl sulfate; (b) a water-insoluble conditioning agent, such as a silicone compound or a hydrocarbon compound, like a polydimethylsiloxane; (c) an emulsifying composition comprising (i) a polyhydric compound, such as a glycol, a triol or a polyol, and (ii) a hydrophilic quaternary ammonium compound, such as a quaternary ammonium compound including a fatty amidoalkyl substituent, like a long chain alkamidopropyl quaternary ammonium chloride or an anionic emulsifying surfactant having the general structural formula:         R₁-O-(A)x-CH₂-Y⁻ M⁺ ,   (I) wherein R₁ is an alkyl or an aralkyl group wherein the alkyl group includes about 6 to about 22 carbon atoms, A is an alkylene oxide moiety wherein the alkylene group includes one to about four carbon atoms, x is a number in the range of 4 to about 50, Y is sulfate, sulfonate, carbonate or carboxylate, and M is selected from the group consisting of hydrogen, an alkali metal, an alkaline earth metal, ammonium, an alkylammonium or a hydroxyalkylammonium, wherein the alkyl group includes one to about four carbon atoms; and (d) a suspending agent, in (e) a suitable carrier, that effectively resists phase separation and that cleanses the hair and imparts improved wet stage and improved dry stage conditioning properties to the hair in a single application of the composition is disclosed.

  一种护理型洗发水组合物，包括(a) 阴离子清洁表面活性剂，如烷基醚硫酸盐或烷基硫酸盐，如十二烷基醚硫酸钠或十二烷基硫酸铵； (b) 水不溶性调理剂，如有机硅化合物或烃类化合物，如聚二甲基硅氧烷；(c) 一种乳化组合物，包括：(i) 一种多元醇化合物，如乙二醇、三醇或多元醇；(ii) 一种亲水性季铵盐化合物，如含有脂肪氨基烷基取代基的季铵盐化合物，如长链烷基酰胺丙基季铵盐氯化物，或具有一般结构式的阴离子乳化表面活性剂： R₁-O-(A)x-CH₂-Y- M⁺ , (I) 其中 R₁ 是烷基或芳烷基，其中烷基包括约 6 至约 22 个碳原子；A 是环氧亚烷基，其中亚烷基包括 1 至约 4 个碳原子；x 是 4 至约 50 之间的数字、Y 是硫酸盐、磺酸盐、碳酸盐或羧酸盐，M 选自氢、碱金属、碱土金属、铵、烷基铵或羟基烷基铵组成的组，其中烷基包括 1 至约 4 个碳原子；和 (d) 一种悬浮剂，在 (e) 一种合适的载体中，该组合物能有效地防止相分离，并能在一次施用该组合物的过程中清洁头发，赋予头发改善的湿期和改善的干期调理特性。
• Clear leave-on treatment composition and method
  申请人：HELENE CURTIS, INC.

  公开号：EP0590538A1

  公开（公告）日：1994-04-06

  A transparent leave-on hair treatment composition including capsules of a water insoluble hair-treating compound encased in a shell material, such as gelatin or acacia gum. The aqueous leave-on composition is applied to the hair and the water insoluble hair-treating compound is released from the capsules to treat the hair. The shell disintegrates into sufficiently small residual particles such that the physical and esthetic properties of the hair, like shine and combability, are retained.

  一种透明的免洗护发组合物，包括包裹在明胶或刺槐胶等外壳材料中的不溶于水的护发化合物胶囊。将水性免洗组合物涂在头发上，不溶于水的护发化合物从胶囊中释放出来，对头发进行护理。外壳会分解成足够小的残留颗粒，从而保留头发的物理和美学特性，如光泽和梳理性。
• New endocannabinoid-like compounds and their use
  申请人：RESEARCH & INNOVATION SOC. COOP. A R.L.

  公开号：EP1900365A2

  公开（公告）日：2008-03-19

  The present invention describes compounds deriving from chemical reactions between saturated or monounsaturated acyl derivatives and primary amines or primary alcohols that display specific cannabinoid-like pharmacological activity without exhibiting the central unwanted side effects typical of synthetic cannabinoids or endocannabinoids acting on central cannabinoid (CB1) receptors. These compounds, having this pharmacological activity, may be utilised to prevent or to treat pathological conditions and diseases in mammals, including human subjects, that may undergo a clinical improvement upon their administration.

  本发明描述了由饱和或单不饱和酰基衍生物与伯胺或伯醇之间的化学反应所产生 的化合物，这些化合物显示出类似大麻素的特殊药理活性，而不会表现出合成大麻 素或作用于中枢大麻素（CB1）受体的内源性大麻素所特有的中枢性不良副作用。这些具有这种药理活性的化合物可用于预防或治疗哺乳动物（包括人类）的病理状况和疾病，服用后可改善临床症状。
• TOPICAL HERBAL COMPOSITIONS
  申请人：CLR-Chemisches Laboratorium Dr. Kurt Richter GmbH

  公开号：EP3434256A1

  公开（公告）日：2019-01-30

  The present invention provides topical formulations having an autophagy stimulating and/or heme oxygenase and activating/triggering effect on human skin for cosmetic and pharmaceutical use. Furthermore, the present invention provides topical formulations that trigger production of VEGF-C, reduce melanin synthesis and boost energy and cell function. Moreover, the present invention provides a new process for producing a herbal composition comprising a mixture of components of Bellis perennis L. and optionally Hieracium pilosella by aqueous extraction and the herbal composition comprising a mixture of components produced by the process of the present invention. The pharmaceutical formulations according to the present invention may be used for the treatment or prevention of dark circles under the eye and/or puffy eyes. The herbal composition according to the present invention may also be used in a cosmetic formulation for the cosmetic treatment or prevention of dark circles under the eye and/or puffy eyes.

  本发明提供了对人体皮肤具有自噬刺激和/或血红素加氧酶和激活/触发作用的外用制剂，用于美容和制药。此外，本发明还提供了可触发 VEGF-C 生成、减少黑色素合成并增强能量和细胞功能的外用制剂。 此外，本发明还提供了一种通过水提取法生产草药组合物的新工艺，该草药组合物包含贝壳蕨（Bellis perennis L.）成分的混合物，也可选 Hieracium pilosella，该草药组合物包含通过本发明工艺生产的成分的混合物。 根据本发明的药物制剂可用于治疗或预防黑眼圈和/或眼袋。 根据本发明的草药组合物也可用于化妆品配方，用于治疗或预防黑眼圈和/或眼袋。