1-[(S)-1-(3,3-diphenyl-propyl)-pyrrolidin-3-yl]-3-(2-methyl-quinolin-4-yl)-urea | 676447-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[(S)-1-(3,3-diphenyl-propyl)-pyrrolidin-3-yl]-3-(2-methyl-quinolin-4-yl)-urea
• 英文别名: 1-[(3S)-1-(3,3-diphenylpropyl)pyrrolidin-3-yl]-3-(2-methylquinolin-4-yl)urea
• CAS: 676447-12-4
• 化学式: C₃₀H₃₂N₄O
• 分子量: 464.61
• InChiKey: UQOCWXTYTANLFQ-VWLOTQADSA-N

物化性质

• 沸点：
  633.6±55.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  57.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• 1-Pyridin-4-yl-urea derivatives
  申请人：Aissaoui Hamed

  公开号：US20060094716A1

  公开（公告）日：2006-05-04

  The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.

  本发明涉及新型的1-吡啶-4-基脲衍生物及其相关化合物，以及将其用作制备药物组合物中的活性成分。本发明还涉及相关方面，包括制备该化合物的过程，含有其中一个或多个化合物的药物组合物，特别是它们作为神经激素拮抗剂的用途。
• 1-PYRIDIN-4-YL-UREA DERIVATIVES
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP1554249A2

  公开（公告）日：2005-07-20
• [EN] 1-PYRIDIN-4-YL-UREA DERIVATIVES<br/>[FR] DERIVES DE 1-PYRIDIN-4-YL-UREE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2004026836A2

  公开（公告）日：2004-04-01

  The invention relates to novel 1-pyridyn-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.