2,6-dihydroxy-4-methyl-heptanedioic acid diethyl ester | 93430-81-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,6-dihydroxy-4-methyl-heptanedioic acid diethyl ester
• 英文别名: 2,6-Dihydroxy-4-methyl-heptandisaeure-diaethylester
• CAS: 93430-81-0
• 化学式: C₁₂H₂₂O₆
• 分子量: 262.303
• InChiKey: VELDDVVWTMTIJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.25
• 重原子数：
  18.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  93.06
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  4-methyl-2,6-dioxo-heptanedioic acid diethyl ester 在 乙醇 、 镍 作用下， 160.0 ℃ 、9.81 MPa 条件下， 生成 6-hydroxy-4-methyl-hept-2t-enedioic acid diethyl ester 、 2,6-dihydroxy-4-methyl-heptanedioic acid diethyl ester
  参考文献：
  名称：

  PCR Detection ofCapnocytophagaSpecies in Dental Plaque Samples from Children Aged 2 to 12 Years

  摘要：

  AbstractThe purpose of this study was to detect the presence of Capnocytophaga sputigena, C. ochracea, and C. gingivalis in plaque samples from the toothbrushes of 122 children, using a polymerase chain reaction (PCR) method. The subjects were 25, 85, and 12 children with healthy gingiva, gingivitis, and periodontitis, respectively, ranging in age from 2–12 years old. Plaque samples were collected from all erupted tooth sites using a sterile toothbrush. The mean amount of DNA recovered from the samples was approximately 19.3 μg, which was deemed sufficient for performing a PCR‐based survey. C. sputigena prevalence in healthy, gingivitis, and periodontitis subjects was 48.0%, 36.5% and 25.0%, respectively, that for C. ochracea was 100%, 89.4%, and 50.0%, respectively, and that for C. gingivalis was 96.0%, 84.7%, and 75.0%, respectively. The lowest age of positive subjects was approximately 2 years. Our results showed that C. sputigena was moderately prevalent, whereas C. ochracea and C. gingivalis were commonly detected in the oral cavities of the tested children, suggesting that all of these species become established in the early years.

  DOI：

  10.1111/j.1348-0421.2001.tb01269.x

文献信息

• Onno, Journal des Recherches du Centre National de la Recherche Scientifique, 1960, vol. 11, p. 205,226
  作者：Onno

  DOI：——

  日期：——